Critical impact of radiotherapy protocol compliance and quality in the treatment of retroperitoneal sarcomas: Results from the EORTC 62092-22092 STRASS trial.

Haas, Rick; Stelmes, Jean-Jacques; Zaffaroni, Facundo; Sauvé, Nicolas; Clementel, Enrico; Bar-Deroma, Raquel; Le Péchoux, Cécile; Litière, Saskia; Marreaud, Sandrine; Alyamani, Najlaa; Andratschke, Nicolaus H J; Sangalli, Claudia; Chung, Peter W; Miah, Aisha; Hurkmans, Coen; Gronchi, Alessandro; Bovée, Judith V M G; Gelderblom, Hans; Kasper, Bernd; Weber, Damien Charles; ... (2022). Critical impact of radiotherapy protocol compliance and quality in the treatment of retroperitoneal sarcomas: Results from the EORTC 62092-22092 STRASS trial. Cancer, 128(14), pp. 2796-2805. Wiley 10.1002/cncr.34239

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BACKGROUND

The European Organization for Research and Treatment of Cancer 22092-62092 STRASS trial failed to demonstrate the superiority of neoadjuvant radiotherapy (RT) over surgery alone in patients with retroperitoneal sarcoma. Therefore, an RT quality-assurance program was added to the study protocol to detect and correct RT deviations. The authors report results from the trial RT quality-assurance program and its potential effect on patient outcomes.

METHODS

To evaluate the effect of RT compliance on survival outcomes, a composite end point was created. It combined the information related to planning target volume coverage, target delineation, total dose received, and overall treatment time into 2 groups: non-RT-compliant (NRC) for patients who had unacceptable deviation(s) in any of the previous categories and RT-compliant (RC) otherwise. Abdominal recurrence-free survival (ARFS) and overall survival were compared between the 2 groups using a Cox proportional hazard model adjusted for known prognostic factors.

RESULTS

Thirty-six of 125 patients (28.8%) were classified as NRC, and the remaining 89 patients (71.2%) were classified as RC. The 3-year ARFS rate was 66.8% (95% confidence interval [CI], 55.8%-75.7%) and 49.8% (95% CI, 32.7%-64.8%) for the RC and NRC groups, respectively (adjusted hazard ratio, 2.32; 95% CI, 1.25-4.32; P = .008). Local recurrence after macroscopic complete resection occurred in 13 of 89 patients (14.6%) versus 2 of 36 patients (5.6%) in the RC and NRC groups, respectively.

CONCLUSIONS

The current analysis suggests a significant benefit in terms of ARFS in favor of the RC group. This association did not translate into less local relapses after complete resection in the RC group. Multidisciplinary collaboration and review of cases are critical to avoid geographic misses, especially for rare tumors like retroperitoneal sarcoma.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Weber, Damien Charles

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1097-0142

Publisher:

Wiley

Language:

English

Submitter:

Basak Ginsbourger

Date Deposited:

27 Oct 2022 12:40

Last Modified:

05 Dec 2022 16:27

Publisher DOI:

10.1002/cncr.34239

PubMed ID:

35536104

Uncontrolled Keywords:

protocol compliance quality assurance radiotherapy retroperitoneal sarcomas soft tissue sarcomas

BORIS DOI:

10.48350/174190

URI:

https://boris.unibe.ch/id/eprint/174190

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