Wiest, C; Torrecillos, F; Tinkhauser, G; Pogosyan, A; Morgante, F; Pereira, E A; Tan, H (2022). Finely-tuned gamma oscillations: Spectral characteristics and links to dyskinesia. Experimental neurology, 351, p. 113999. Elsevier 10.1016/j.expneurol.2022.113999
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Gamma oscillations comprise a loosely defined, heterogeneous group of functionally different activities between 30 and 100 Hz in the cortical and subcortical local field potential (LFP) of the motor network. Two distinct patterns seem to emerge which are easily conflated: Finely-tuned gamma (FTG) oscillations - a narrowband activity with peaks between 60 and 90 Hz - have been observed in multiple movement disorders and are induced by dopaminergic medication or deep brain stimulation (DBS). FTG has been linked with levodopa or DBS-induced dyskinesias, which makes it a putative biomarker for adaptive DBS. On the other hand, gamma activity can also present as a broad phenomenon (30-100 Hz) in the context of motor activation and dynamic processing. Here, we contrast FTG, either levodopa-induced or DBS-induced, from movement-related broadband gamma synchronisation and further elaborate on the functional role of FTG and its potential implications for adaptive DBS. Given the unclear distinction of FTG and broad gamma in literature, we appeal for more careful separation of the two. To better characterise cortical and subcortical FTG as biomarkers for dyskinesia, their sensitivity and specificity need to be investigated in a large clinical trial.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Tinkhauser, Gerd |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0014-4886 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
02 Nov 2022 08:20 |
Last Modified: |
05 Dec 2022 16:27 |
Publisher DOI: |
10.1016/j.expneurol.2022.113999 |
PubMed ID: |
35143832 |
Uncontrolled Keywords: |
Adaptive deep brain stimulation Dyskinesia Finely-tuned gamma Local field potentials Movement-related gamma synchronisation Narrowband gamma Oscillations Parkinson's disease |
BORIS DOI: |
10.48350/174405 |
URI: |
https://boris.unibe.ch/id/eprint/174405 |
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