Ruehl, Ria Maxine; Flanagin, Virginia L; Ophey, Leoni; Raiser, Theresa Marie; Seiderer, Katharina; Ertl, Matthias; Conrad, Julian; Zu Eulenburg, Peter (2022). The human egomotion network. NeuroImage, 264(119715), p. 119715. Elsevier 10.1016/j.neuroimage.2022.119715
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All volitional movement in a three-dimensional space requires multisensory integration, in particular of visual and vestibular signals. Where and how the human brain processes and integrates self-motion signals remains enigmatic. Here, we applied visual and vestibular self-motion stimulation using fast and precise whole-brain neuroimaging to delineate and characterize the entire cortical and subcortical egomotion network in a substantial cohort (n=131). Our results identify a core egomotion network consisting of areas in the cingulate sulcus (CSv, PcM/pCi), the cerebellum (uvula), and the temporo-parietal cortex including area VPS and an unnamed region in the supramarginal gyrus. Based on its cerebral connectivity pattern and anatomical localization, we propose that this region represents the human homologue of macaque area 7a. Whole-brain connectivity and gradient analyses imply an essential role of the connections between the cingulate sulcus and the cerebellar uvula in egomotion perception. This could be via feedback loops involved updating visuo-spatial and vestibular information. The unique functional connectivity patterns of PcM/pCi hint at central role in multisensory integration essential for the perception of self-referential spatial awareness. All cortical egomotion hubs showed modular functional connectivity with other visual, vestibular, somatosensory and higher order motor areas, underlining their mutual function in general sensorimotor integration.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
07 Faculty of Human Sciences > Institute of Psychology |
UniBE Contributor: |
Ertl, Matthias |
Subjects: |
100 Philosophy > 150 Psychology |
ISSN: |
1095-9572 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
09 Nov 2022 10:48 |
Last Modified: |
14 Dec 2022 00:15 |
Publisher DOI: |
10.1016/j.neuroimage.2022.119715 |
PubMed ID: |
36334557 |
Uncontrolled Keywords: |
CSv Egomotion Functional Connectivity Human Area 7a Neuroimaging PcM/pCi Uvula VPS |
BORIS DOI: |
10.48350/174530 |
URI: |
https://boris.unibe.ch/id/eprint/174530 |
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