3DPolyS-LE: an accessible simulation framework to model the interplay between chromatin and loop extrusion.

Gitchev, Todor; Zala, Gabriel; Meister, Peter; Jost, Daniel (2022). 3DPolyS-LE: an accessible simulation framework to model the interplay between chromatin and loop extrusion. Bioinformatics, 38(24), pp. 5454-5456. Oxford University Press 10.1093/bioinformatics/btac705

Preview

Text btac705.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (3MB) | Preview

SUMMARY

Recent studies suggest that the loop extrusion activity of Structural Maintenance of Chromosomes complexes is central to proper organization of genomes in vivo. Polymer physics-based modeling of chromosome structure has been instrumental to assess which structures such extrusion can create. Only few laboratories however have the technical and computational expertise to create in silico models combining dynamic features of chromatin and loop extruders. Here we present 3DPolyS-LE, a self-contained, easy to use modeling and simulation framework allowing non-specialists to ask how specific properties of loop extruders and boundary elements impact on 3D chromosome structure. 3DPolyS-LE also provides algorithms to compare predictions with experimental Hi-C data.

AVAILABILITY

Software available at https://gitlab.com/togop/3DPolyS-LE; implemented in Python and Fortran 2003 and supported on any Unix-based operating system (Linux, Mac OS).

SUPPLEMENTARY INFORMATION

Supplementary information are available at Bioinformatics online.

Interest & Impact

Downloads

32 since deposited on 16 Nov 2022
32 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item