Apaza Alccayhuaman, Karol Alí; Heimel, Patrick; Lee, Jung Seok; Tangl, Stefan; Kuchler, Ulrike; Marchesan, Julie; Panahipour, Layla; Lettner, Stefan; Matalová, Eva; Gruber, Reinhard (2023). FasL is a catabolic factor in alveolar bone homeostasis. Journal of clinical periodontology, 50(3), pp. 396-405. Wiley 10.1111/jcpe.13750
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J_Clinic_Periodontology_-_2022_-_Apaza_Alccayhuaman_-_FasL_is_a_catabolic_factor_in_alveolar_bone_homeostasis.pdf - Accepted Version Available under License Publisher holds Copyright. Download (1MB) | Preview |
AIM
Fas ligand (FasL) belongs to the tumor necrosis factor (TNF) superfamily regulating bone turnover, inflammation, and apoptosis. The appendicular and axial skeleton phenotype of mature Faslgld mice was reported. The impact of FasL on the alveolar bone providing support for the teeth at mature stages under healthy and induced inflammatory conditions remains unknown.
MATERIALS AND METHODS
We performed a phenotypical analysis of mice carrying the homozygous Faslgld mutation and wild-type (WT) mice (C57BL/6) under healthy conditions and upon ligature-induced periodontitis. After 12 days, μCT analysis revealed the distance between the cement enamel junction and the alveolar bone crest (CEJ-ABC). Additional structural parameters like the bone volume fraction (BV/TV) and the periodontal ligament space volume (PLS.V) were measured. Histological analyses were performed to visualize the catabolic changes at the defect site.
RESULTS
We report that healthy Faslgld mice have more periodontal bone than wild-type littermates. Faslgld had no significant effect on inflammatory osteolysis compared to WT controls with ligatures. Histology revealed eroded surfaces at the root and in the interproximal bone in both strains.
CONCLUSIONS
These findings suggest that FasL is a catabolic factor in alveolar bone homeostasis, however, FasL does not affect the inflammatory osteolysis. This article is protected by copyright. All rights reserved.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Gruber, Reinhard |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0303-6979 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
23 Nov 2022 10:02 |
Last Modified: |
17 Nov 2023 00:25 |
Publisher DOI: |
10.1111/jcpe.13750 |
PubMed ID: |
36384160 |
Uncontrolled Keywords: |
FasL Faslgld mouse histology micro-CT mouse model periodontal structure periodontitis |
BORIS DOI: |
10.48350/174886 |
URI: |
https://boris.unibe.ch/id/eprint/174886 |
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