Vallesi, Vanessa; Richter, Johannes K; Hunkeler, Nadine; Abramovic, Mihael; Hashagen, Claus; Christiaanse, Ernst; Shetty, Ganesh; Verma, Rajeev K; Berger, Markus; Frotzler, Angela; Eisenlohr, Heidrun; Eriks-Hoogland, Inge; Scheel-Sailer, Anke; Michels, Lars; Wyss, Patrik O (2022). Functional connectivity and amplitude of low-frequency fluctuations changes in people with complete subacute and chronic spinal cord injury. Scientific Reports, 12(1), p. 20874. Nature Publishing Group 10.1038/s41598-022-25345-5
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After spinal cord injury (SCI), reorganization processes and changes in brain connectivity occur. Besides the sensorimotor cortex, the subcortical areas are strongly involved in motion and executive control. This exploratory study focusses on the cerebellum and vermis. Resting-state functional magnetic resonance imaging (fMRI) was performed. Between-group differences were computed using analysis of covariance and post-hoc tests for the seed-based connectivity measure with vermis and cerebellum as regions of interest. Twenty participants with complete SCI (five subacute SCI, 15 with chronic SCI) and 14 healthy controls (HC) were included. Functional connectivity (FC) was lower in all subjects with SCI compared with HC in vermis IX, right superior frontal gyrus (pFDR = 0.008) and right lateral occipital cortex (pFDR = 0.036). In addition, functional connectivity was lower in participants with chronic SCI compared with subacute SCI in bilateral cerebellar crus I, left precentral- and middle frontal gyrus (pFDR = 0.001). Furthermore, higher amplitude of low-frequency fluctuations (ALFF) was found in the left thalamus in individuals with subacute SCI (pFDR = 0.002). Reduced FC in SCI indicates adaptation with associated deficit in sensory and motor function. The increased ALFF in subacute SCI might reflect reorganization processes in the subacute phase.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology |
UniBE Contributor: |
Richter, Johannes Konstantin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
05 Dec 2022 09:51 |
Last Modified: |
11 Dec 2022 02:11 |
Publisher DOI: |
10.1038/s41598-022-25345-5 |
PubMed ID: |
36463248 |
BORIS DOI: |
10.48350/175468 |
URI: |
https://boris.unibe.ch/id/eprint/175468 |
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