In Vitro Validation of a New Tissue Oximeter Using Visible Light.

Nasseri, Nassim; Kleiser, Stefan; Wolf, Ursula; Wolf, Martin (2022). In Vitro Validation of a New Tissue Oximeter Using Visible Light. In: Oxygen Transport to Tissue XLIII. Advances in Experimental Medicine and Biology: Vol. 1395 (pp. 217-221). New York: Springer 10.1007/978-3-031-14190-4_36

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There is a clinical need to measure local tissue oxygen saturation (StO2), oxy-, deoxy- and total haemoglobin concentration ([O2Hb], [HHb], [tHb]) in human tissue. The aim was to validate an oximeter called OxyVLS applying visible light spectroscopy (VLS) to determine these parameters without needing to assume a reduced scattering coefficient (μ's). This problem is solved by appropriate calibrations. Compared to near-infrared spectroscopy (NIRS), OxyVLS determines the oxygenation in a much smaller more superficial volume of tissue, which is useful in many clinical cases. OxyVLS was validated in liquid phantoms with known StO2, [tHb], and μ's and compared to frequency domain NIRS as a reliable reference. OxyVLS showed a high accuracy for all the mentioned parameters and was even able to measure μ's. Thus, OxyVLS was successfully tested in vitro.

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