Familiari, A; Napolitano, R; Visser, G H A; Lees, C; Wolf, H; Prefumo, F (2023). Antenatal corticosteroids and perinatal outcome in late fetal growth restriction: analysis of prospective cohort. Ultrasound in obstetrics & gynecology, 61(2), pp. 191-197. Wiley 10.1002/uog.26127
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Ultrasound_in_Obstet_Gyne_-_2022_-_Familiari_-_Antenatal_corticosteroids_and_perinatal_outcome_in_late_fetal_growth.pdf - Accepted Version Available under License Publisher holds Copyright. Download (717kB) | Preview |
OBJECTIVE
The aim of this study is to evaluate the possible role of antenatal administration of corticosteroids for fetal lung maturation on short term perinatal outcomes in late FGR.
METHODS
This cohort study is a secondary analysis of a multicenter prospective observational study, the TRUFFLE-2 feasibility study, conducted between 2017 and 2018 in 33 European perinatal centers. We included women with singleton pregnancy from 32+0 to 36+6 weeks of gestation with a fetus considered at risk for FGR, defined as estimated fetal weight (EFW) or abdominal circumference (AC) <10th centile, or umbilico-cerebral ratio (UCR) >95th centile, or a fall of more than 40 centile points in AC measurement from the 20 weeks scan. The primary adverse outcome was a composite of abnormal condition at birth or major neonatal morbidity.
RESULTS
A total of 86 pregnancies who received antenatal corticosteroids (exposed) were matched with non-exposed pregnancies. Both groups were similar regarding gestational age at inclusion (33 weeks), EFW (1673 g) and UCR (0.68), gestational age at delivery (35.5 weeks) and birth weight (1925 g); the presented values are for both groups combined. No significant differences were observed between exposed and non-exposed for composite adverse outcome (28% vs. 24%; p=0.73) or for any of its elements.
CONCLUSION
The present data do not show a beneficial effect of steroids on short term outcomes in fetuses with late FGR. This article is protected by copyright. All rights reserved.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1469-0705 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Monika Zehr |
Date Deposited: |
11 Jan 2023 17:28 |
Last Modified: |
24 Nov 2023 00:25 |
Publisher DOI: |
10.1002/uog.26127 |
PubMed ID: |
36412975 |
Additional Information: |
TRUFFLE 2 Feasibility Study investigators: Raio, Luigi |
Uncontrolled Keywords: |
antenatal corticosteroids fetal growth restriction fetal lung maturation late preterm |
BORIS DOI: |
10.48350/176820 |
URI: |
https://boris.unibe.ch/id/eprint/176820 |
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