Pietsch, Urs; Fischer, Henning; Rüst, Christoph Alexander; Hossfeld, Björn; Grünenfelder, Andreas; Wenzel, Volker; Albrecht, Roland (2023). Oral transmucosal fentanyl citrate analgesia in prehospital trauma care: an observational cohort study. Scandinavian journal of trauma, resuscitation and emergency medicine, 31(1), p. 2. BioMed Central 10.1186/s13049-023-01066-0
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BACKGROUND
Pain is one of the major prehospital symptoms in trauma patients and requires prompt management. Recent studies have reported insufficient analgesia after prehospital treatment in up to 43% of trauma patients, leaving significant room for improvement. Good evidence exists for prehospital use of oral transmucosal fentanyl citrate (OTFC) in the military setting. We hypothesized that the use of OTFC for trauma patients in remote and challenging environment is feasible, efficient, safe, and might be an alternative to nasal and intravenous applications.
METHODS
This observational cohort study examined 177 patients who were treated with oral transmucosal fentanyl citrate by EMS providers in three ski and bike resorts in Switzerland. All EMS providers had previously been trained in administration of the drug and handling of potential adverse events.
RESULTS
OTFC caused a statistically significant and clinically relevant decrease in the level of pain by a median of 3 (IQR 2 to 4) in NRS units (P < 0.0001). Multiple linear regression analysis showed a significant absolute reduction in pain, with no differences in all age groups and between genders. No major adverse events were observed.
CONCLUSIONS
Prehospital administration of OTFC is safe, easy, and efficient for extrication and transport across all age groups, gender, and types of injuries in alpine environments. Side effects were few and mild. This could provide a valuable alternative in trauma patients with severe pain, without the delay of inserting an intravenous line, especially in remote areas, where fast action and easy administration are important.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center |
UniBE Contributor: |
Pietsch, Urs, Albrecht, Roland |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1757-7241 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
10 Jan 2023 17:28 |
Last Modified: |
15 Jan 2023 02:19 |
Publisher DOI: |
10.1186/s13049-023-01066-0 |
PubMed ID: |
36609399 |
Uncontrolled Keywords: |
Fentanyl HEMS OTFC Prehospital analgesia Trauma support |
BORIS DOI: |
10.48350/177037 |
URI: |
https://boris.unibe.ch/id/eprint/177037 |
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