Neocortical Pyramidal Cells Respond as Integrate-and-Fire Neurons to In Vivo–Like Input Currents

Rauch, Alexander; La Camera, Giancarlo; Lüscher, Hans-Rudolf; Senn, Walter; Fusi, Stefano (2003). Neocortical Pyramidal Cells Respond as Integrate-and-Fire Neurons to In Vivo–Like Input Currents. Journal of neurophysiology, 90(3), pp. 1598-1612. American Physiological Society 10.1152/jn.00293.2003

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In the intact brain neurons are constantly exposed to intense synaptic activity. This heavy barrage of excitatory and inhibitory inputs was recreated in vitro by injecting a noisy current, generated as an Ornstein–Uhlenbeck process, into the soma of rat neocortical pyramidal cells. The response to such in vivo–like currents was studied systematically by analyzing the time development of the instantaneous spike frequency, and when possible, the stationary mean spike frequency as a function of both the mean and the variance of the input current. All cells responded with an in vivo–like action potential activity with stationary statistics that could be sustained throughout long stimulation intervals (tens of seconds), provided the frequencies were not too high. The temporal evolution of the response revealed the presence of mechanisms of fast and slow spike frequency adaptation, and a medium duration mechanism of facilitation. For strong input currents, the slow adaptation mechanism made the spike frequency response nonstationary. The minimal frequencies that caused strong slow adaptation (a decrease in the spike rate by more than 1 Hz/s), were in the range 30–80 Hz and depended on the pipette solution used. The stationary response function has been fitted by two simple models of integrate-and-fire neurons endowed with a frequency-dependent modification of the input current. This accounts for all the fast and slow mechanisms of adaptation and facilitation that determine the stationary response, and proved necessary to fit the model to the experimental data. The coefficient of variability of the interspike interval was also in part captured by the model neurons, by tuning the parameters of the model to match the mean spike frequencies only. We conclude that the integrate-and-fire model with spike-frequency–dependent adaptation/facilitation is an adequate model reduction of cortical cells when the mean spike-frequency response to in vivo–like currents with stationary statistics is considered.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology

UniBE Contributor:

Rauch, Alexander, La Camera, Giancarlo, Lüscher, Hans-Rudolf, Senn, Walter, Fusi, Stefano

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-3077

Publisher:

American Physiological Society

Language:

English

Submitter:

Virginie Sabado

Date Deposited:

18 Jan 2023 16:04

Last Modified:

18 Jan 2023 23:28

Publisher DOI:

10.1152/jn.00293.2003

PubMed ID:

12750422

BORIS DOI:

10.48350/177221

URI:

https://boris.unibe.ch/id/eprint/177221

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