Brandstetter, Viktoria; Schmidt, Jarno M; Findji, Laurent; Selmic, Laura E; Murgia, Daniela; de Mello Souza, Carlos H; Liehmann, Lea M; L'Eplattenier, Henry; Tichy, Alexander; Vincenti, Simona (2023). Feline primary nonhematopoietic malignant liver tumors: A multicenter retrospective study (2000-2021). Veterinary and comparative oncology, 21(2), pp. 191-199. Wiley 10.1111/vco.12874
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Vet_Comparative_Oncology_-_2023_-_Brandstetter_-_Feline_primary_nonhematopoietic_malignant_liver_tumors_A_multicenter.pdf - Accepted Version Available under License Publisher holds Copyright. Download (339kB) | Preview |
There is scant literature on primary nonhematopoietic malignant liver tumors (PMLT) in cats. In this retrospective study, medical data of 40 cats diagnosed with PMLT were reviewed over a period of 22 years (2000-2021). The most frequent epithelial tumors were hepatocellular (42.5%) and bile duct carcinomas (32.5%), only six (15%) cats had mesenchymal tumors. The median age was 13 years and clinical signs commonly included ano-/hyporexia (62.5%), apathy/lethargy (52.5%), weight loss (42.5%) and vomiting (35%). At initial diagnosis, metastases were confirmed in 1 (2.5%) and suspected in three (7.5%) cats. Massive was the most frequent morphology (75%). Most intrahepatic tumors were left-sided (54.2%) with the left medial lobe being primarily affected (25%). Extrahepatic tumors were rare (5%). In 34 (85%) cats, liver lobectomy was performed (surgery group), four (10%) were treated palliatively (non-surgery group), and two (5%) received no treatment. Intraoperative complications occurred in 11.8% with four (15.4%) postoperative deaths. Recurrence was detected in 28.6% at a median of 151 days (range, 79-684 days), while postoperative metastases were suspected in 21.4% at a median of 186 days (range, 79-479 days). The median survival time (MST) was significantly longer in cats of the surgery group (375 days) than in the non-surgery group (16 days) (P = 0.002). MST was 868 days for hepatocellular compared to 270 days for bile duct carcinomas (P = 0.06). In summary, liver lobectomy is associated with prolonged survival times and good prognosis in cats with hepatocellular, and an acceptable prognosis in cats with bile duct carcinoma.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) |
UniBE Contributor: |
Vincenti, Simona |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
1476-5810 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
20 Jan 2023 13:22 |
Last Modified: |
13 Jan 2024 00:25 |
Publisher DOI: |
10.1111/vco.12874 |
PubMed ID: |
36635958 |
Uncontrolled Keywords: |
Bile duct carcinoma Cats Hepatocellular Liver neoplasia Prognosis Surgical treatment |
BORIS DOI: |
10.48350/177397 |
URI: |
https://boris.unibe.ch/id/eprint/177397 |