Breit, Sigrid; Mazza, Elena; Poletti, Sara; Benedetti, Francesco (2023). White matter integrity and pro-inflammatory cytokines as predictors of antidepressant response in MDD. Journal of psychiatric research, 159, pp. 22-32. Elsevier 10.1016/j.jpsychires.2022.12.009
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Major depressive disorder (MDD) is a multifactorial, serious and heterogeneous mental disorder that can lead to chronic recurrent symptoms, treatment resistance and suicidal behavior. MDD often involves immune dysregulation with high peripheral levels of inflammatory cytokines that might have an influence on the clinical course and treatment response. Moreover, patients with MDD show brain volume changes as well as white matter (WM) alterations that are already existing in the early stage of illness. Mounting evidence suggests that both neuroimaging markers, such as WM integrity and blood markers, such as inflammatory cytokines might serve as predictors of treatment response in MDD. However, the relationship between peripheral inflammation, WM structure and antidepressant response is not yet clearly understood. The aim of the present review is to elucidate the association between inflammation and WM integrity and its impact on the pathophysiology and progression of MDD as well as the role of possible novel biomarkers of treatment response to improve MDD prevention and treatment strategies.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center |
UniBE Contributor: |
Breit, Sigrid |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0022-3956 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
20 Jan 2023 12:41 |
Last Modified: |
24 Feb 2023 00:15 |
Publisher DOI: |
10.1016/j.jpsychires.2022.12.009 |
PubMed ID: |
36657311 |
Uncontrolled Keywords: |
Biomarkers Immune dysregulation Inflammatory cytokines MDD White matter integrity |
BORIS DOI: |
10.48350/177705 |
URI: |
https://boris.unibe.ch/id/eprint/177705 |
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