Conroy, Andrea L; Datta, Dibyadyuti; Hoffmann, Angelika; Wassmer, Samuel C (2023). The kidney-brain pathogenic axis in severe falciparum malaria. Trends in parasitology, 39(3), pp. 191-199. Elsevier Current Trends 10.1016/j.pt.2023.01.005
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Severe falciparum malaria is a medical emergency and a leading cause of death and neurodisability in endemic areas. Common complications include acute kidney injury (AKI) and cerebral malaria, and recent studies have suggested links between kidney and brain dysfunction in Plasmodium falciparum infection. Here, we review these new findings and present the hypothesis of a pivotal pathogenic crosstalk between the kidneys and the brain in severe falciparum malaria. We highlight the evidence of a role for distant organ involvement in the development of cerebral malaria and subsequent neurocognitive impairment post-recovery, describe the challenges associated with current diagnostic shortcomings for both AKI and brain involvement in severe falciparum malaria, and explore novel potential therapeutic strategies.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology |
UniBE Contributor: |
Hoffmann, Angelika |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1471-4922 |
Publisher: |
Elsevier Current Trends |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
07 Feb 2023 10:15 |
Last Modified: |
18 Feb 2023 00:16 |
Publisher DOI: |
10.1016/j.pt.2023.01.005 |
PubMed ID: |
36737313 |
Uncontrolled Keywords: |
Plasmodium falciparum brain, kidney injury cerebral malaria pathogenesis severe malaria |
BORIS DOI: |
10.48350/178360 |
URI: |
https://boris.unibe.ch/id/eprint/178360 |
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