Utilization of livers donated after circulatory death for transplantation - An international comparison.

Eden, Janina; Da Silva, Richard Sousa; Cortes-Cerisuelo, Miriam; Croome, Kristopher; De Carlis, Riccardo; Hessheimer, Amelia J; Muller, Xavier; de Goeij, Femke; Banz, Vanessa; Magini, Giulia; Compagnon, Philippe; Elmer, Andreas; Lauterio, Andrea; Panconesi, Rebecca; Widmer, Jeannette; Dondossola, Daniele; Muiesan, Paolo; Monbaliu, Diethard; de Rosner van Rosmalen, Marieke; Detry, Olivier; ... (2023). Utilization of livers donated after circulatory death for transplantation - An international comparison. Journal of hepatology, 78(5), pp. 1007-1016. Elsevier 10.1016/j.jhep.2023.01.025

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BACKGROUND AND AIM

Liver graft utilization rates are a hot topic due to the worldwide organ shortage and an increasing number of transplant candidates on waiting lists. Liver perfusion techniques have been introduced in several countries, and may help to increase the organ supply, as they potentially allow the assessment of livers before use.

METHODS

Liver offers were counted from donation after circulatory death (DCD) donors (Maastricht-type-III) arising during the past decade in eight countries, including Belgium, France, Italy, the Netherlands, Spain, Switzerland, UK, and US. Initial DCD-type-III liver offers were correlated with accepted, recovered and implanted livers.

RESULTS

A total number of 34`269 DCD livers were offered, resulting in 9`780 liver transplants (28.5%). The discard rates were highest in UK and US, ranging between 70 and 80%. In contrast, much lower DCD liver discard rates, e.g., between 30-40%, were found in Belgium, France, Italy, Spain and Switzerland. In addition, large differences were recognized in the use of various machine perfusion techniques, and in terms of risk factors in the cohorts of implanted livers. For example, the median donor age and functional donor warm ischemia were highest in Italy, e.g., >40minutes, followed by Switzerland, France, and the Netherlands. Importantly, such varying risk profiles of accepted DCD livers between countries did not translate into large differences in five-year graft survival rates, which ranged between 60-82% in this analysis.

CONCLUSIONS

We highlight a significant number of discarded and consequently unused DCD liver offers. Countries with more routine use of in- and ex-situ machine perfusion strategies showed better DCD utilization rates without compromised outcome.

IMPACT AND IMPLICATIONS

A significant number of Maastricht type III DCD livers are discarded across Europe and North America today. The overall utilization rate among eight Western countries is 28.5%, but varies significantly between 18.9% and 74.2%. For example, the median DCD III liver utilization in five countries, e.g., Belgium, France, Italy, Switzerland, and Spain is 65%, in contrast to 24% in the Netherlands, UK and US. Despite this, and despite different rules and strategies for organ acceptance and preservation, the one and five-year graft survival remains currently relatively comparable among all participating countries. Factors which impact on DCD liver acceptance rates include the national pre-selections of donors, before the offer is made, as well as cutoffs for key risk factors, including donor age and donor warm ischemia time. In addition, a highly varying experience with modern machine perfusion technology is noticed. In situ and ex situ liver perfusion concepts, and assessment tools for type III DCD livers before transplantation may be one key part for the observed differences in better DCD III utilization.

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