Koenders, Niek; van Zetten, Henrita; Smulders, Michelle; Verra, Martin L; van Kimmenade, Roland R J; van Brakel, Thomas; Eijsvogels, Thijs M H; Smith, Tim (2023). Outcomes after cardiac rehabilitation in patients following repair of thoracic aortic aneurysm or dissection: a protocol for a systematic review and meta-analysis. Systematic Reviews, 12(1), p. 16. BioMed Central 10.1186/s13643-023-02180-x
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BACKGROUND
Patients receiving thoracic aortic repair suffer from long-term impairment in daily functioning and quality of life following intervention due to a combination of their life-threatening condition (i.e. aortic aneurysm or dissection), undergoing major surgery, as well as long-term exercise restrictions thereafter. Despite the known risks of exercise, it is vital that patients regain physical activity in order to recover their daily functioning and quality of life. Cardiac rehabilitation could be a safe and effective treatment to support patients to become physically active by providing exercise training, comprehensive rehabilitation services, and safety recommendations. Despite new insights in recent literature and clinical practice, international guidelines do not recommend cardiac rehabilitation due to limited evidence. We aim to fill this knowledge gap by performing a systematic review and meta-analysis on the effectiveness of cardiac rehabilitation in patients following thoracic aortic repair.
METHODS
This protocol has been developed following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). MEDLINE, Embase, and CINAHL will be searched for eligible observational and interventional studies from inception up to April 2022. Screening (title/abstract and full text), data extraction, risk of bias assessment, and therapeutic validity rating will be conducted by two independent reviewers. A random-effects model will be used to meta-analyse performance-based outcomes, patient-reported outcomes, clinician-reported outcomes, and researcher-reported outcomes. Subsequently, meta-bias and confidence in evidence will be analysed by two independent reviewers.
DISCUSSION
To exercise or not to exercise in patients following thoracic aortic repair has been a topic of discussion for years. The intended systematic review and meta-analysis will provide comprehensive evidence on the effectiveness of phase III outpatient exercise-based cardiac rehabilitation in patients following thoracic aortic repair. Findings from this review may inform future guidelines for the management of patients with thoracic aortic disease.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42022301204.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology |
UniBE Contributor: |
Verra, Martin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2046-4053 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
09 Feb 2023 08:43 |
Last Modified: |
12 Feb 2023 02:26 |
Publisher DOI: |
10.1186/s13643-023-02180-x |
PubMed ID: |
36750901 |
Uncontrolled Keywords: |
Aortic rupture Cardiac rehabilitation Dissecting aneurysm Exercise Thoracic aorta |
BORIS DOI: |
10.48350/178557 |
URI: |
https://boris.unibe.ch/id/eprint/178557 |
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