Bingöl, Anne Carolin; Bingöl, Memduh; Pandis, Nikolaos; Stolz, Simone; Beblo, Skadi; Jost-Brinkmann, Paul-Georg; Mönch, Eberhard; Bartzela, Theodosia (2023). Dietary and metabolic effects on the oral status of patients with phenylketonuria: a nation-based cross-sectional study. Clinical oral investigations, 27(5), pp. 1981-1991. Springer-Verlag 10.1007/s00784-022-04827-w
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OBJECTIVES
The aim of this study was to compare the prevalence of oral diseases (caries, periodontal disease, enamel defects) between patients with phenylketonuria (PKU), their siblings, and a matched control group.
MATERIALS AND METHODS
A total of 109 patients with PKU, 14 siblings of PKU patients, and 100 healthy individuals aged 6 to 68 years were recruited. All participants completed a questionnaire based on their health status. The patients' decayed/missing/filled teeth index (dmft/DMFT), gingival bleeding index (GBI), plaque control record (PCR), periodontal screening and recording index (PSR), and developmental enamel defects index (DDE) were recorded. Descriptive statistics and regression modeling were used to examine potential associations between the exposure and the outcomes of interest.
RESULTS
Patients with PKU had 1.6 times more caries (95% confidence interval (CI) 1.22 to 2.20; p = 0.001), seven times more enamel defects (95% CI 3.94 to 14.21; p < 0.001), and four times higher PSR values (95% CI 2.26 to 7.15; p < 0.001) than the control group. The siblings had significantly fewer enamel defects but no significant differences in caries and periodontal parameters compared to the PKU patients.
CONCLUSIONS
The results showed a higher risk for the development of caries, periodontitis, and enamel defects in PKU patients.
CLINICAL RELEVANCE
Implementation of preventive measures and regular dental care is necessary for patients with PKU.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics |
UniBE Contributor: |
Pandis, Nikolaos |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1432-6981 |
Publisher: |
Springer-Verlag |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
23 Feb 2023 12:49 |
Last Modified: |
05 May 2023 00:14 |
Publisher DOI: |
10.1007/s00784-022-04827-w |
PubMed ID: |
36805804 |
Uncontrolled Keywords: |
Caries Enamel defects Oral health Oral status Phenylketonuria |
BORIS DOI: |
10.48350/179059 |
URI: |
https://boris.unibe.ch/id/eprint/179059 |
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