Stanikić, Mina; Twomey, Eric; Puhan, Milo A; Kamm, Christian P; Salmen, Anke; Ajdacic-Gross, Vladeta; Zecca, Chiara; Gobbi, Claudio; von Wyl, Viktor (2023). Experiences of persons with multiple sclerosis with the Covid-19 vaccination: A cross-sectional study of the Swiss Multiple Sclerosis Registry. Multiple sclerosis and related disorders, 74, p. 104707. Elsevier 10.1016/j.msard.2023.104707
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BACKGROUND
Despite strong recommendations for coronavirus disease 2019 (Covid-19) vaccination by multiple sclerosis (MS) organizations, some persons with MS (pwMS) remain vaccine hesitant. The Swiss MS Registry conducted a survey to explore Covid-19 vaccine hesitancy, self-reported side effects and changes in MS symptoms following vaccination in adult pwMS.
METHODS
Self-reported data were analyzed cross-sectionally. Multivariable logistic regression was used to explore participant characteristics associated with Covid-19 vaccine hesitancy.
RESULTS
Of 849 respondents, 73 (8.6%) were unvaccinated. Hesitation to vaccinate was most often a personal preference (N = 42, 57.53%). Factors negatively associated with vaccine hesitancy included older age (OR = 0.97 per year, 95% CI [0.94, 0.99]) and regularly seeing healthcare professionals (OR = 0.25, 95% CI [0.07, 0.85]). A history of confirmed Covid-19 infection (OR = 3.38, 95% CI [1.69, 6.77]) and being underweight (OR = 4.50, 95% CI [1.52, 13.36]) were positively associated with vaccine hesitancy. Of 768 participants who provided information, 320 (41.2%) and 351 (45.2%) reported vaccination side effects after the first and second vaccinations, respectively. Changes in MS symptoms were reported by 49 (6.3%) participants after the first and 67 (9.0%) participants after the second vaccination, and were most often described as increased or new-onset fatigue (N = 17/49 (34.7%) after the first and N = 21/67 (31.3%) after the second dose).
CONCLUSIONS
Covid-19 vaccine hesitancy was low among surveyed pwMS. The risk of vaccine hesitancy was higher among younger pwMS, those with a history of Covid-19 infection, and those without regular contact with healthcare professionals.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Kamm, Christian Philipp |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2211-0356 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
18 Apr 2023 11:26 |
Last Modified: |
18 Jun 2023 00:15 |
Publisher DOI: |
10.1016/j.msard.2023.104707 |
PubMed ID: |
37068368 |
Uncontrolled Keywords: |
Covid-19 Multiple sclerosis Side effects Vaccination Vaccine hesitancy |
BORIS DOI: |
10.48350/181815 |
URI: |
https://boris.unibe.ch/id/eprint/181815 |
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