Sache, Antoine; Reymond, Philippe; Brina, Olivier; Jung, Bernd; Farhat, Mohamed; Vargas, Maria Isabel (2023). Near-wall hemodynamic parameters quantification in in vitro intracranial aneurysms with 7 T PC-MRI. Magma, 36(2), pp. 295-308. Springer 10.1007/s10334-023-01082-2
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OBJECTIVE
Wall shear stress (WSS) and its derived spatiotemporal parameters have proven to play a major role on intracranial aneurysms (IAs) growth and rupture. This study aims to demonstrate how ultra-high field (UHF) 7 T phase contrast magnetic resonance imaging (PC-MRI) coupled with advanced image acceleration techniques allows a highly resolved visualization of near-wall hemodynamic parameters patterns in in vitro IAs, paving the way for more robust risk assessment of their growth and rupture.
MATERIALS AND METHODS
We performed pulsatile flow measurements inside three in vitro models of patient-specific IAs using 7 T PC-MRI. To this end, we built an MRI-compatible test bench, which faithfully reproduced a typical physiological intracranial flow rate in the models.
RESULTS
The ultra-high field 7 T images revealed WSS patterns with high spatiotemporal resolution. Interestingly, the high oscillatory shear index values were found in the core of low WSS vortical structures and in flow stream intersecting regions. In contrast, maxima of WSS occurred around the impinging jet sites.
CONCLUSIONS
We showed that the elevated signal-to-noise ratio arising from 7 T PC-MRI enabled to resolve high and low WSS patterns with a high degree of detail.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology |
UniBE Contributor: |
Jung, Bernd |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1352-8661 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
19 Apr 2023 10:39 |
Last Modified: |
28 Apr 2023 00:16 |
Publisher DOI: |
10.1007/s10334-023-01082-2 |
PubMed ID: |
37072539 |
Uncontrolled Keywords: |
7 T phase contrast MRI Hemodynamics In vitro models Intracranial aneurysms Wall shear stress |
BORIS DOI: |
10.48350/181842 |
URI: |
https://boris.unibe.ch/id/eprint/181842 |
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