Mackowiak, Adèle L C; Roy, Christopher W; Yerly, Jérôme; Falcão, Mariana B L; Bacher, Mario; Speier, Peter; Piccini, Davide; Stuber, Matthias; Bastiaansen, Jessica A M (2023). Motion-resolved fat-fraction mapping with whole-heart free-running multiecho GRE and pilot tone. Magnetic resonance in medicine, 90(3), pp. 922-938. Wiley-Liss 10.1002/mrm.29680
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Magnetic_Resonance_in_Med_-_2023_-_Mackowiak_-_Motion_resolved_fat_fraction_mapping_with_whole_heart_free_running_multiecho.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (10MB) | Preview |
PURPOSE
To develop a free-running 3D radial whole-heart multiecho gradient echo (ME-GRE) framework for cardiac- and respiratory-motion-resolved fat fraction (FF) quantification.
METHODS
(NTE = 8) readouts optimized for water-fat separation and quantification were integrated within a continuous non-electrocardiogram-triggered free-breathing 3D radial GRE acquisition. Motion resolution was achieved with pilot tone (PT) navigation, and the extracted cardiac and respiratory signals were compared to those obtained with self-gating (SG). After extra-dimensional golden-angle radial sparse parallel-based image reconstruction, FF, R2 *, and B0 maps, as well as fat and water images were generated with a maximum-likelihood fitting algorithm. The framework was tested in a fat-water phantom and in 10 healthy volunteers at 1.5 T using NTE = 4 and NTE = 8 echoes. The separated images and maps were compared with a standard free-breathing electrocardiogram (ECG)-triggered acquisition.
RESULTS
The method was validated in vivo, and physiological motion was resolved over all collected echoes. Across volunteers, PT provided respiratory and cardiac signals in agreement (r = 0.91 and r = 0.72) with SG of the first echo, and a higher correlation to the ECG (0.1% of missed triggers for PT vs. 5.9% for SG). The framework enabled pericardial fat imaging and quantification throughout the cardiac cycle, revealing a decrease in FF at end-systole by 11.4% ± 3.1% across volunteers (p < 0.0001). Motion-resolved end-diastolic 3D FF maps showed good correlation with ECG-triggered measurements (FF bias of -1.06%). A significant difference in free-running FF measured with NTE = 4 and NTE = 8 was found (p < 0.0001 in sub-cutaneous fat and p < 0.01 in pericardial fat).
CONCLUSION
Free-running fat fraction mapping was validated at 1.5 T, enabling ME-GRE-based fat quantification with NTE = 8 echoes in 6:15 min.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
?? 31DEB2B84C3366FAE053980C5C8240B8 ?? 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology |
UniBE Contributor: |
Bastiaansen, Jessica |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0740-3194 |
Publisher: |
Wiley-Liss |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
28 Apr 2023 10:44 |
Last Modified: |
30 Jan 2024 15:50 |
Publisher DOI: |
10.1002/mrm.29680 |
PubMed ID: |
37103471 |
Uncontrolled Keywords: |
3D radial cardiac MRI fat quantification motion multiecho GRE parametric mapping pilot tone |
BORIS DOI: |
10.48350/182043 |
URI: |
https://boris.unibe.ch/id/eprint/182043 |
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