Plant extracts have dual mechanism on the protection against dentine erosion: action on the dentine substrate and modification of the salivary pellicle

Niemeyer, Samira Helena; Baumann, Tommy; Lussi, Adrian; Scaramucci, Tais; Saads Carvalho, Thiago (2023). Plant extracts have dual mechanism on the protection against dentine erosion: action on the dentine substrate and modification of the salivary pellicle. Scientific reports, 13(1) Springer Nature 10.1038/s41598-023-34256-y

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To investigate the effect of some polyphenol-rich plant extracts on the protection of dentine against
demineralization, both acting on the dentine and on the salivary pellicle. Dentine specimens (n = 180)
were randomly distributed into 6 experimental groups (n = 30/group): Control (deionized water), Açaí
extract, Blueberry extract, Green tea extract, Grape seed extract, and Sn2+/
F− (mouthrinse containing
stannous and fluoride). Each group was further divided into two subgroups (n = 15), according to the
site of action of the substance: on the dentine surface (D) or on the salivary pellicle (P). The specimens
were submitted to 10 cycles: 30 min incubation in human saliva (P) or only in humid chamber (D), 2 min
immersion in experimental substances, 60 min of incubation in saliva (P) or not (D), and 1 min erosive
challenge. Dentine surface loss (DSL), amount of degraded collagen (dColl) and total calcium release
were analyzed. Green tea, Grape seed and Sn2+/
F− showed significant protection, with least DSL and
dColl. The Sn2+/
F− showed better protection on D than on P, whereas Green tea and Grape seed showed
a dual mode of action, with good results on D, and even better on P. Sn2+/
F− showed the lowest values
of calcium release, not differing only from Grape seed. Sn2+/
F− is more effective when acting directly
on the dentine surface, while Green tea and Grape seed have a dual mode of action: with a positive
effect on the dentine surface itself, but an improved efficacy in the presence of the salivary pellicle.
We further elucidate the mechanism of action of different active ingredients on dentine erosion,
where Sn2+/
F− acts better on the dentine surface, but plant extracts have a dual mode of action,
acting on the dentine itself as well as on the salivary pellicle, improving the protection against acid
demineralization.

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