Wagenhäuser, Isabell; Reusch, Julia; Gabel, Alexander; Mees, Juliane; Nyawale, Helmut; Frey, Anna; Lâm, Thiên-Trí; Schubert-Unkmeir, Alexandra; Dölken, Lars; Kurzai, Oliver; Frantz, Stefan; Petri, Nils; Krone, Manuel; Krone, Lukas B (2024). The relationship between mental health, sleep quality and the immunogenicity of COVID-19 vaccinations. Journal of sleep research, 33(3), e13929. Wiley 10.1111/jsr.13929
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Sleep modulates the immune response, and sleep loss can reduce vaccine immunogenicity; vice versa, immune responses impact sleep. We aimed to investigate the influence of mental health and sleep quality on the immunogenicity of COVID-19 vaccinations and, conversely, of COVID-19 vaccinations on sleep quality. The prospective CoVacSer study monitored mental health, sleep quality and Anti-SARS-CoV-2-Spike IgG titres in a cohort of 1082 healthcare workers from 29 September 2021 to 19 December 2022. Questionnaires and blood samples were collected before, 14 days, and 3 months after the third COVID-19 vaccination, as well as in 154 participants before and 14 days after the fourth COVID-19 vaccination. Healthcare workers with psychiatric disorders had slightly lower Anti-SARS-CoV-2-Spike IgG levels before the third COVID-19 vaccination. However, this effect was mediated by higher median age and body mass index in this subgroup. Antibody titres following the third and fourth COVID-19 vaccinations ("booster vaccinations") were not significantly different between subgroups with and without psychiatric disorders. Sleep quality did not affect the humoral immunogenicity of the COVID-19 vaccinations. Moreover, the COVID-19 vaccinations did not impact self-reported sleep quality. Our data suggest that in a working population neither mental health nor sleep quality relevantly impact the immunogenicity of COVID-19 vaccinations, and that COVID-19 vaccinations do not cause a sustained deterioration of sleep, suggesting that they are not a precipitating factor for insomnia. The findings from this large-scale real-life cohort study will inform clinical practice regarding the recommendation of COVID-19 booster vaccinations for individuals with mental health and sleep problems.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy |
UniBE Contributor: |
Krone, Lukas Bernhard |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1365-2869 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
15 May 2023 08:58 |
Last Modified: |
15 May 2024 00:11 |
Publisher DOI: |
10.1111/jsr.13929 |
PubMed ID: |
37177872 |
Uncontrolled Keywords: |
COVID-19 vaccination immune response psychiatric disorders sleep function sleep regulation system consolidation |
BORIS DOI: |
10.48350/182527 |
URI: |
https://boris.unibe.ch/id/eprint/182527 |
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