Spontaneous regeneration of keratinized tissue at implants and teeth.

Imber, Jean-Claude; Roccuzzo, Andrea; Stähli, Alexandra; Bosshardt, Dieter D; Muñoz, Fernando; Ramseier, Christoph A; Lang, Niklaus P; Sculean, Anton (2023). Spontaneous regeneration of keratinized tissue at implants and teeth. Journal of clinical periodontology, 50(8), pp. 1064-1074. Wiley 10.1111/jcpe.13820

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AIM

To investigate the spontaneous regeneration of the implanto-mucosal and dento-gingival unit after complete removal of keratinized tissue (KT).

MATERIALS AND METHODS

One hemi-mandible per dog (n = 4) was allocated to receive three dental implants (test sites, premolar region), whereas three premolars on the contralateral side were controls. After osseointegration, the entire KT (buccal + lingual) was surgically excised on all test and control sites, leaving the bone exposed. Clinical measurements were performed before excision (T0 ) and after 12 weeks (T1 ). Following healing, the animals were euthanized, and the specimens were histologically processed. Descriptive statistical analyses were performed.

RESULTS

Clinical measurements revealed that at T1 , on all teeth, a band of KT was spontaneously regenerated (mean width: 2.60 ± 0.66 mm), whereas on implants, KT was detected only occasionally at mesial or distal but not at buccal sites (mean total: 0.35 ± 0.53 mm; p < .0001). Histologically, spontaneous regeneration of the dento-gingival unit was evident, displaying masticatory mucosa. At the implant sites, on the other hand, the implanto-mucosal unit was characterized by a non-keratinized epithelium and elastic fibres, indicating the characteristics encountered in alveolar mucosa.

CONCLUSION

After excision of KT at implant sites, the spontaneous regeneration of the soft tissue is characterized by a non-keratinized epithelium typical for alveolar mucosa, while at tooth sites the spontaneous regeneration was characterized by soft tissue resembling gingiva.

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