Frauscher, Birgit; Bartolomei, Fabrice; Baud, Maxime O.; Smith, Rachel J; Worrell, Greg; Lundstrom, Brian N (2023). Stimulation to probe, excite, and inhibit the epileptic brain. Epilepsia, 64 Suppl 3(Suppl 3), S49-S61. Wiley 10.1111/epi.17640
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Epilepsia_-_2023_-_Frauscher_-_Stimulation_to_probe_excite_and_inhibit_the_epileptic_brain.pdf - Accepted Version Available under License Publisher holds Copyright. Download (8MB) | Preview |
Direct cortical stimulation has been applied in epilepsy for nearly one century and has experienced a renaissance given unprecedented opportunities to probe, excite and inhibit the human brain. Evidence suggests stimulation can increase diagnostic and therapeutic utility in patients with drug-resistant epilepsies. However, choosing appropriate stimulation parameters is not a trivial issue, which is further complicated by the fact that epilepsy is characterized by complex brain state dynamics. In this article derived from discussions at the ICTALS 2022 conference, we succinctly review the literature on cortical stimulation applied acutely and chronically to the epileptic brain for localization, monitoring, and therapeutic purposes. In particular, we discuss how stimulation is used to probe brain excitability, discuss evidence on usefulness of stimulation to trigger and stop seizures, review therapeutic applications of stimulation, and finally discuss how stimulation parameters are impacted by brain dynamics. Although research has advanced considerably over the past decade, there are still significant hurdles to optimize use of this technique. For example, it remains unclear to what extent short timescale diagnostic biomarkers can predict long-term outcomes and to what extent these biomarkers add information to already existing biomarkers from passive EEG recordings. Further questions include the extent to which closed loop stimulation offers advantages over open loop stimulation, what the optimal closed loop timescales may be, and whether biomarker-informed stimulation can lead to seizure freedom. The ultimate goal of bioelectronic medicine remains not just to stop seizures but rather to cure epilepsy and its comorbidities.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Baud, Maxime |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1528-1167 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
19 May 2023 11:56 |
Last Modified: |
19 May 2024 00:25 |
Publisher DOI: |
10.1111/epi.17640 |
PubMed ID: |
37194746 |
Uncontrolled Keywords: |
deep brain stimulation diagnosis electrical stimulation epilepsy treatment |
BORIS DOI: |
10.48350/182668 |
URI: |
https://boris.unibe.ch/id/eprint/182668 |
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