Dobbelaere, Dirk,; Küenzi, P (2004). The strategies of the Theileria parasite: a new twist in host-pathogen interactions. Current opinion in immunology, 16(4), pp. 524-30. Kidlington, UK: Elsevier 10.1016/j.coi.2004.05.009
Full text not available from this repository.Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-kappa B (nuclear factor kappa B) activation is accomplished by recruiting the IKK (I kappa B kinase) complex, a central regulator of NF-kappa B pathways, to the surface of the transforming schizont, where it becomes permanently activated. Constitutive activation of the PI-3K-PKB [phosphoinositide 3-kinase-(Akt) protein kinase B] pathway is likely to be indirect and is essential for continuous proliferation. Theileria-transformed T cells express a range of anti-apoptotic proteins that can be expected to provide protection against apoptosis induced by death receptors, as well as cellular control mechanisms that are mobilised to eliminate cells that entered a cycle of uncontrolled proliferation.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology |
UniBE Contributor: |
Dobbelaere, Dirk, |
ISSN: |
0952-7915 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:44 |
Last Modified: |
05 Dec 2022 14:13 |
Publisher DOI: |
10.1016/j.coi.2004.05.009 |
PubMed ID: |
15245750 |
Web of Science ID: |
000222919200021 |
URI: |
https://boris.unibe.ch/id/eprint/18406 (FactScience: 460) |
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