Chackartchi, Tali; Bosshardt, Dieter D; Imber, Jean-Claude; Stähli, Alexandra; Sacks, Hagit; Nagy, Katalin; Sculean, Anton (2023). Histological evaluation following treatment of recession-type defects with coronally advanced flap and a novel human recombinant amelogenin. Clinical oral investigations, 27(9), pp. 5041-5048. Springer 10.1007/s00784-023-05123-x
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OBJECTIVES
To histologically evaluate the effects of a novel human recombinant amelogenin (rAmelX) on periodontal wound healing / regeneration in recession-type defects.
MATERIALS AND METHODS
A total of 17 gingival recession-type defects were surgically created in the maxilla of three minipigs. The defects were randomly treated with a coronally advanced flap (CAF) and either rAmelX (test), or a CAF and placebo (control). At three months following reconstructive surgery, the animals were euthanized, and the healing outcomes histologically evaluated.
RESULTS
The test group yielded statistically significantly (p = 0.047) greater formation of cementum with inserting collagen fibers compared with the control group (i.e., 4.38 mm ± 0.36 mm vs. 3.48 mm ± 1.13 mm). Bone formation measured 2.15 mm ± 0.8 mm in the test group and 2.24 mm ± 1.23 mm in the control group, respectively, without a statistically significant difference (p = 0.94).
CONCLUSIONS
The present data have provided for the first-time evidence for the potential of rAmelX to promote regeneration of periodontal ligament and root cementum in recession-type defects, thus warranting further preclinical and clinical testing.
CLINICAL RELEVANCE
The present results set the basis for the potential clinical application of rAmelX in reconstructive periodontal surgery.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Bosshardt, Dieter, Imber, Jean-Claude, Stähli, Alexandra Beatrice, Sculean, Anton |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1436-3771 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
10 Jul 2023 10:56 |
Last Modified: |
11 Sep 2023 00:14 |
Publisher DOI: |
10.1007/s00784-023-05123-x |
PubMed ID: |
37421492 |
Uncontrolled Keywords: |
Gingival recessions Periodontal regeneration Periodontal wound healing Recombinant Amelogenin |
BORIS DOI: |
10.48350/184608 |
URI: |
https://boris.unibe.ch/id/eprint/184608 |
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