Diamantaras, A A; Blondiaux, E; Schumacher, R; Müri, R M; Blanke, O; Heydrich, L (2023). The neuropsychology and neuroanatomy of reduplicative paramnesia. Cortex, 167, pp. 12-24. Elsevier 10.1016/j.cortex.2023.06.006
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Reduplicative paramnesia refers to the delusional belief that there are identical places in different locations. In this case-control study we investigated the clinical, phenomenological, neuropsychological and neuroanatomical data of eleven patients with reduplicative paramnesia and compared them against a control group of eleven patients with severe spatial disorientation without signs of reduplicative paramnesia. We show that most patients with reduplicative paramnesia report that a current place is reduplicated and/or relocated to an other familiar place. Patients with reduplicative paramnesia show a higher prevalence of deficits in the executive functions compared to the control patients, while mnestic and visuo-spatial deficits were both frequent in patients with reduplicative paramnesia and the control group. Patients with reduplicative paramnesia mostly suffer from right hemispheric lesions with a maximal overlap in the dorsolateral prefrontal cortex. Using lesion network mapping we show that lesions causing reduplicative paramnesia are connected to bilateral anterior insula and the right cingulate cortex. We argue that patients with reduplicative paramnesia fail to integrate the actual context with visuo-spatial memories and personal relevant emotional information due to a disruption of the neural network within the anterior temporal lobe, the cingulate cortex and the anterior insula. Also patients with reduplicative paramnesia are not able to resolve this conflict due to the lesion of the dorsolateral prefrontal cortex and executive dysfunction.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Diamantaras, Andreas Antonios, Schumacher, Rahel, Müri, René Martin, Heydrich, Lukas Emmanuel Josef Marc |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1973-8102 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
31 Jul 2023 13:42 |
Last Modified: |
02 Oct 2023 00:14 |
Publisher DOI: |
10.1016/j.cortex.2023.06.006 |
PubMed ID: |
37515831 |
Uncontrolled Keywords: |
Dorsolateral prefrontal cortex Insula Lesion network mapping Lesion overlap analysis Reduplicative paramnesia |
BORIS DOI: |
10.48350/185136 |
URI: |
https://boris.unibe.ch/id/eprint/185136 |
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