Stute, Petra; Walker, Linus Josef; Eicher, Astrid; Pavicic, Elena; Kolokythas, Argyrios; Theis, Susanne; von Gernler, Marc; von Wolff, Michael; Vollrath, Sabrina (2024). Progestogens for endometrial protection in combined menopausal hormone therapy: A systematic review. Best practice & research. Clinical endocrinology & metabolism, 38(1), p. 101815. Elsevier 10.1016/j.beem.2023.101815
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Menopausal women with an intact uterus choosing estrogens for menopausal symptom relief require a progestogen for endometrial protection. The aim of this systematic review was to evaluate the risks of endometrial hyperplasia resp. malignancy with different progestogens used in combined MHT. Overall, 84 RCTs were included. We found that 1) most studies were done with NETA, followed by MPA, MP and DYD and LNG, 2) most progestogens were only available as oral formulations, 3) the most frequently studied progestogens (oral MP, DYD, MPA, oral and transdermal NETA, transdermal LNG) were assessed in continuously as well as in sequentially combined MHT regimens, 4) FDA endometrial safety criteria were only fulfilled for some progestogen formulations, 5) most studies demonstrated endometrial protection for the progestogen dose and time period examined. However, 6) study quality varied which should be taken into account, when choosing a combined MHT, especially if off-label-use is chosen.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology 13 Central Units > Administrative Director's Office > University Library of Bern |
UniBE Contributor: |
Stute, Petra, von Gernler, Marc Simon, von Wolff, Michael, Baumgartner, Sabrina Josefine |
Subjects: |
600 Technology > 610 Medicine & health 000 Computer science, knowledge & systems > 020 Library & information sciences |
ISSN: |
1878-1594 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
30 Aug 2023 16:17 |
Last Modified: |
22 Jan 2024 00:12 |
Publisher DOI: |
10.1016/j.beem.2023.101815 |
PubMed ID: |
37634998 |
Uncontrolled Keywords: |
endometrial biopsy endometrial cancer endometrial hyperplasia menopausal hormone therapy progestogens |
BORIS DOI: |
10.48350/185792 |
URI: |
https://boris.unibe.ch/id/eprint/185792 |
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