Jahren, Silje Ekroll; Martinez, Thomas; Walter, Armando; Ferrari, Lorenzo; Clavica, Francesco; Obrist, Dominik; Civet, Yoan; Perriard, Yves (2023). Hemodynamic effects of a dielectric elastomer augmented aorta on aortic wave intensity: An in-vivo study. Journal of biomechanics, 159, p. 111777. Elsevier 10.1016/j.jbiomech.2023.111777
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Dielectric elastomer actuator augmented aorta (DEA) represents a novel approach with high potential for assisting a failing heart. The soft tubular device replaces a section of the aorta and increases its diameter when activated. The hemodynamic interaction between the DEA and the left ventricle (LV) has not been investigated with wave intensity (WI) analysis before. The objective of this study is to investigate the hemodynamic effects of the DEA on the aortic WI pattern. WI was calculated from aortic pressure and flow measured in-vivo in the descending aorta of two pigs implanted with DEAs. The DEAs were tested for different actuation phase shifts (PS). The DEA generated two decompression waves (traveling upstream and downstream of the device) at activation followed by two compression waves at deactivation. Depending on the PS, the end-diastolic pressure (EDP) decreased by 7% (or increased by 5–6%). The average early diastolic pressure augmentation (P_dia) increased by 2% (or decreased by 2–3%). The hydraulic work (W_H) measured in the aorta decreased by 2% (or increased by 5%). The DEA-generated waves interfered with the LV-generated waves, and the timing of the waves affected the hemodynamic effect of the device. For the best actuation timing the upstream decompression wave arrived just before aortic valve opening and the upstream compression wave arrived just before aortic valve closure leading to a decreased EDP, an increased P_dia and a reduced W_H.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE) 10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research |
UniBE Contributor: |
Jahren, Silje Ekroll, Ferrari, Lorenzo, Clavica, Francesco, Obrist, Dominik |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health 600 Technology 600 Technology > 620 Engineering |
ISSN: |
1873-2380 |
Publisher: |
Elsevier |
Funders: |
[UNSPECIFIED] Werner Siemens Stiftung |
Language: |
English |
Submitter: |
Silje Ekroll Jahren |
Date Deposited: |
05 Sep 2023 10:29 |
Last Modified: |
01 Oct 2023 00:17 |
Publisher DOI: |
10.1016/j.jbiomech.2023.111777 |
PubMed ID: |
37666100 |
Uncontrolled Keywords: |
Aortic counterpulsation Arterial hemodynamics Cardiac assist device Wave intensity analysis |
BORIS DOI: |
10.48350/186007 |
URI: |
https://boris.unibe.ch/id/eprint/186007 |
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