Corso, Pascal; Obrist, Dominik (September 2023). On the role of aortic valve architecture for physiological haemodynamics and valve replacement. Part II: spectral analysis and anisotropy Research Square 10.21203/rs.3.rs-3387570/v1
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Severe aortic valve stenosis can lead to heart failure and aortic valve replacement (AVR) is the primary treatment. However, increasing prevalence of aortic stenosis cases reveal limitations in current replacement options, necessitating improved prosthetic aortic valves.
In this study, we investigate flow disturbances downstream of severe aortic stenosis and two bioprosthetic aortic valve (BioAV) designs using advanced energy-based analyses.
Spectral analysis shows kinetic energy (KE) decay variations, with the stenotic case aligning with Kolmogorov's theory, while BioAVs differ. We explore the impact of flow helicity on KE transfer and decay in BioAVs. Probability distributions of modal KE anisotropy unveil flow asymmetries in the stenotic and one BioAV case. Moreover, an inverse correlation between modal KE anisotropy and normalised helicity intensity is noted, with the coefficient of determination varying among the valve configurations. Leaflet dynamics analysis highlights a stronger correlation between flow and biomechanical KE anisotropy in one BioAV due to higher leaflet displacement magnitude. These findings emphasise the role of valve architecture in aortic turbulence and its significance for BioAV performance and energy-based design optimisation.
Item Type: |
Working Paper |
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Division/Institute: |
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE) |
UniBE Contributor: |
Corso, Pascal, Obrist, Dominik |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 530 Physics 600 Technology > 620 Engineering |
ISSN: |
2693-5015 |
Publisher: |
Research Square |
Language: |
English |
Submitter: |
Pascal Corso |
Date Deposited: |
28 Sep 2023 13:43 |
Last Modified: |
28 Sep 2023 13:52 |
Publisher DOI: |
10.21203/rs.3.rs-3387570/v1 |
Uncontrolled Keywords: |
Aortic stenosis, Bioprosthetic aortic valves, Flow turbulence, Fluid-Structure Interaction simulations, Kinetic energy anisotropy, Spectral analysis, Valve design |
BORIS DOI: |
10.48350/186730 |
URI: |
https://boris.unibe.ch/id/eprint/186730 |
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