Intact Mismatch Negativity Responses in Clinical High-Risk for Psychosis and First-Episode Psychosis: Evidence from Source-Reconstructed Event-Related Fields and Time-Frequency Data.

Dheerendra, Pradeep; Grent-'t-Jong, Tineke; Gajwani, Ruchika; Gross, Joachim; Gumley, Andrew I; Krishnadas, Rajeev; Lawrie, Stephen M; Schwannauer, Matthias; Schultze-Lutter, Frauke; Uhlhaas, Peter J (2024). Intact Mismatch Negativity Responses in Clinical High-Risk for Psychosis and First-Episode Psychosis: Evidence from Source-Reconstructed Event-Related Fields and Time-Frequency Data. Biological psychiatry. Cognitive neuroscience and neuroimaging, 9(1), pp. 121-131. Elsevier 10.1016/j.bpsc.2023.09.006

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BACKGROUND

To examine whether Mismatch Negativity (MMN) Responses are impaired in participants at clinical high-risk for psychosis (CHR-P) and first episode psychosis (FEP) patients and whether MMN-deficits predict clinical outcomes in CHR-Ps.

METHODS

Magnetoencephalography (MEG) data were collected during a duration-deviant MMN-paradigm for a group of 116 CHR-P participants, 33 FEP patients, (15 antipsychotic-naïve), a psychosis-risk-negative group (CHR-N: n=38) with substance abuse and affective disorder and 49 healthy controls (HC). Analysis of group differences of source-reconstructed event-related fields as well as time-frequency and inter-trial-phase-coherence (ITPC) focused on bilateral Heschl's gyri and superior temporal gyri.

RESULTS

Significant MMNm responses were found across participants in bilateral Heschl's gyrus and superior temporal gyri. However, MMN-amplitude as well as time-frequency and ITPC-responses were intact in CHR-P and FEP-patients relative to HC. Furthermore, MMN-deficits were not related to persistent attenuated psychotic symptoms nor transitions to psychosis in CHR-Ps.

CONCLUSIONS

Our data suggest that MMNm responses in MEG-data are not impaired in early-stage psychosis and may not predict clinical outcomes in CHR-P participants.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy

UniBE Contributor:

Schultze-Lutter, Frauke

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2451-9030

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

02 Oct 2023 12:56

Last Modified:

09 Jan 2024 00:13

Publisher DOI:

10.1016/j.bpsc.2023.09.006

PubMed ID:

37778724

Uncontrolled Keywords:

Magnetoencephalography Mismatch Negativity Psychosis High Risk Schizophrenia Source-Reconstruction Time-Frequency Analysis

BORIS DOI:

10.48350/186845

URI:

https://boris.unibe.ch/id/eprint/186845

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