Canullo, Luigi; Donato, Antonacci; Savadori, Paolo; Radovanovic, Sandro; Iacono, Roberta; Rakic, Mia (2024). Effect of argon plasma abutment activation on soft tissue healing: RCT with histological assessment. Clinical implant dentistry and related research, 26(1), pp. 226-236. Wiley 10.1111/cid.13286
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Clin_Implant_Dent_Rel_Res_-_2023_-_Canullo_-_Effect_of_argon_plasma_abutment_activation_on_soft_tissue_healing_RCT_with.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (5MB) | Preview |
OBJECTIVE
To assess the peri-implant soft tissue profiles between argon plasma treatment (PT) and non-treated (NPT) healing abutments by comparing clinical and histological parameters 2 months following abutment placement.
MATERIALS AND METHODS
Thirty participants were randomly assigned to argon-plasma treatment abutments group (PT) or non-treated abutments (NPT) group. Two months after healing abutment placement, soft peri-implant tissues and abutment were harvested, and histological and clinical parameters including plaque index, bleeding on probing, and keratinized mucosa diameter (KM) were assessed. Specialized stainings (hematoxylin-eosin and picrocirious red) coupled with immunohistochemistry (vimentin, collagen, and CK10) were performed to assess soft tissue inflammation and healing, and the collagen content keratinization. In addition to standard statistical methods, machine learning algorithms were applied for advanced soft tissue profiling between the test and control groups.
RESULTS
PT group showed lower plaque accumulation and inflammation grade (6.71% vs. 13.25%, respectively; p-value 0.02), and more advanced connective tissue healing and integration compared to NPT (31.77% vs. 23.3%, respectively; p = 0.009). In the control group, more expressed keratinization was found compared to the PT group, showing significantly higher CK10 (>47.5%). No differences in KM were found between the groups.
SIGNIFICANCE
PT seems to be a promising protocol for guided peri-implant soft tissue morphogenesis reducing plaque accumulation and inflammation, and stimulating collagen and soft tissue but without effects on epithelial tissues and keratinization.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Canullo, Luigi |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1708-8208 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
19 Oct 2023 11:23 |
Last Modified: |
09 Feb 2024 00:13 |
Publisher DOI: |
10.1111/cid.13286 |
PubMed ID: |
37853303 |
Uncontrolled Keywords: |
MLA abutments argon plasma collagen cytokeratin 10 decontamination peri-implant soft tissues vimentin |
BORIS DOI: |
10.48350/187291 |
URI: |
https://boris.unibe.ch/id/eprint/187291 |
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