The IASLC Lung Cancer Staging Project: Proposals for the Revision of the N Descriptors in the Forthcoming 9th Edition of the TNM Classification for Lung Cancer.

Huang, James; Osarogiagbon, Raymond U; Giroux, Dorothy J; Nishimura, Katherine K; Bille, Andrea; Cardillo, Giuseppe; Detterbeck, Frank; Kernstine, Kemp; Kim, Hong Kwan; Lievens, Yolande; Lim, Eric; Marom, Edith; Prosch, Helmut; Putora, Paul Martin; Rami-Porta, Ramon; Rice, David; Rocco, Gaetano; Rusch, Valerie W; Opitz, Isabelle; Vasquez, Francisco Suarez; ... (2024). The IASLC Lung Cancer Staging Project: Proposals for the Revision of the N Descriptors in the Forthcoming 9th Edition of the TNM Classification for Lung Cancer. Journal of thoracic oncology, 19(5), pp. 766-785. Elsevier 10.1016/j.jtho.2023.10.012

[img] Text
1-s2.0-S1556086423023109-main.pdf - Accepted Version
Restricted to registered users only until 20 October 2024.
Available under License Publisher holds Copyright.

Download (1MB)

INTRODUCTION

The accurate assessment of nodal (N) status is crucial to the management and prognostication of non-metastatic non-small cell lung cancer. We sought to determine whether the current N descriptors should be maintained or revised for the upcoming 9th edition of the international Tumor Node Metastasis (TNM) lung cancer staging system.

METHODS

Data was assembled by the International Association for the Study of Lung Cancer on patients with non-small cell lung cancer, detailing both clinical and pathologic N status, with information about anatomic location and individual station-level identification. Survival was calculated by the Kaplan-Meier method and prognostic groups were assessed by a Cox regression analysis.

RESULTS

Data for clinical N and pathologic N status were available in 45,032 and 35,009 patients, respectively. The current N0 to N3 descriptors for both clinical N and pathologic N categories demonstrated prognostically distinct groups. Furthermore, single station N2 involvement (N2a) demonstrated better prognosis than multistation N2 involvement (N2b) in both clinical and pathologic classifications, and the differences between all neighboring nodal subcategories were highly significant. The prognostic differences between N2a and N2b were robust and consistent across resection status, histologic type, T category, and geographic region.

CONCLUSIONS

The current N descriptors should be maintained, with the addition of new sub-descriptors to N2 for single station involvement (N2a) and multiple station involvement (N2b).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Putora, Paul Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1556-1380

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

23 Oct 2023 13:56

Last Modified:

10 May 2024 00:12

Publisher DOI:

10.1016/j.jtho.2023.10.012

PubMed ID:

37866624

Uncontrolled Keywords:

Lung cancer Lung cancer staging Lymph node metastasis N component N descriptors TNM classification

BORIS DOI:

10.48350/187366

URI:

https://boris.unibe.ch/id/eprint/187366

Actions (login required)

Edit item Edit item
Provide Feedback