Ducray, Angélique; Qualls, Rachel; Schlattner, Uwe; Andres, Robert H; Dreher, Ekkehard; Seiler, Rolf W; Wallimann, Theo; Widmer, Hans Rudolf (2007). Creatine promotes the GABAergic phenotype in human fetal spinal cord cultures. Brain research, 1137(1), pp. 50-7. Amsterdam: Elsevier 10.1016/j.brainres.2006.12.038
Full text not available from this repository.In the present study, we investigated the expression pattern of cytosolic brain specific-BB-CK and ubiquitous mitochondrial-creatine kinases (uMt-CK) in developing human spinal cord. Consequently, we studied the effects of creatine treatment on cultured fetal human spinal cord tissue. We found that both CK isoforms were expressed in fetal spinal cord at all time points investigated (5 to 11.5 weeks post conception) and correspondingly specific CK activity was detected. Chronic creatine exposure resulted in significantly higher densities of GABA-immunoreactive neurons in the cultures, while total neuronal cell density was not altered, suggesting a differentiation inducing mechanism of creatine supplementation. Taken together, our observations favour the view that the creatine phosphocreatine system plays an important role in the developing CNS.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
Ducray, Angélique, Andres, Robert, Dreher, Ekkehard, Seiler, Rolf, Widmer, Hans Rudolf |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0006-8993 |
ISBN: |
17223088 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:45 |
Last Modified: |
05 Dec 2022 14:14 |
Publisher DOI: |
10.1016/j.brainres.2006.12.038 |
PubMed ID: |
17223088 |
Web of Science ID: |
000244849300006 |
URI: |
https://boris.unibe.ch/id/eprint/18821 (FactScience: 1059) |
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