3D printing injectable microbeads using a composite liposomal ink for local treatment of peritoneal diseases.

Eugster, Remo; Ganguin, Aymar Abel; Seidi, Amirmohammad; Aleandri, Simone; Luciani, Paola (2024). 3D printing injectable microbeads using a composite liposomal ink for local treatment of peritoneal diseases. Drug delivery and translational research, 14(6), pp. 1567-1581. Springer 10.1007/s13346-023-01472-y

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The peritoneal cavity offers an attractive administration route for challenging-to-treat diseases, such as peritoneal carcinomatosis, post-surgical adhesions, and peritoneal fibrosis. Achieving a uniform and prolonged drug distribution throughout the entire peritoneal space, though, is difficult due to high clearance rates, among others. To address such an unmet clinical need, alternative drug delivery approaches providing sustained drug release, reduced clearance rates, and a patient-centric strategy are required. Here, we describe the development of a 3D-printed composite platform for the sustained release of the tyrosine kinase inhibitor gefitinib (GEF), a small molecule drug with therapeutic applications for peritoneal metastasis and post-surgical adhesions. We present a robust method for the production of biodegradable liposome-loaded hydrogel microbeads that can overcome the pharmacokinetic limitations of small molecules with fast clearance rates, a current bottleneck for the intraperitoneal (IP) administration of these therapeutics. By means of an electromagnetic droplet printhead, we 3D printed microbeads employing an alginate-based ink loaded with GEF-containing multilamellar vesicles (MLVs). The sustained release of GEF from microbeads was demonstrated. In vitro studies on an immortalized human hepatic cancer cell line (Huh-7) proved concentration-dependent cell death. These findings demonstrate the potential of 3D-printed alginate microbeads containing liposomes for delivering small drug compounds into the peritoneum, overcoming previous limitations of IP drug delivery.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Eugster, Remo, Ganguin, Aymar Abel, Aleandri, Simone, Luciani, Paola

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry
000 Computer science, knowledge & systems

ISSN:

2190-3948

Publisher:

Springer

Language:

English

Submitter:

Pubmed Import

Date Deposited:

27 Nov 2023 10:23

Last Modified:

28 Apr 2024 00:12

Publisher DOI:

10.1007/s13346-023-01472-y

PubMed ID:

38006449

Uncontrolled Keywords:

3D printing Drop-on-demand manufacturing Hydrogel microbeads Liposomes Peritoneal drug delivery Sustained drug release

BORIS DOI:

10.48350/189429

URI:

https://boris.unibe.ch/id/eprint/189429

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