Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia

Pabst, Thomas; Stillner, Erica; Neuberg, Donna; Nimer, Stephen; Willman, Cheryl L; List, Alan F; Melo, Junia V; Tenen, Daniel G; Mueller, Beatrice U (2006). Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia. British journal of haematology, 133(4), pp. 400-2. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2006.06057.x

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The transcription factor CEBPA is crucial for normal myeloid differentiation. CEBPA gene mutations have been reported in patients with acute myeloid leukaemia. The inevitable evolution of chronic myeloid leukaemia (CML) in chronic phase (CP) to a fatal blast crisis (BC) is assumed to result from the acquisition of additional genetic changes in the leukaemic clone. Gain of CEBPA mutations might represent a key event causing the differentiation block observed in myeloid CML-BC, but not in CML-CP. Here, no CEBPA mutation in 95 CML-BC patients was found, suggesting a limited role, if any, of CEBPA mutations in this disorder.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine
UniBE Contributor:	Pabst, Thomas Niklaus, Müller, Beatrice Ursula
ISSN:	0007-1048
ISBN:	16643447
Publisher:	Wiley-Blackwell
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:46
Last Modified:	02 Mar 2023 23:22
Publisher DOI:	10.1111/j.1365-2141.2006.06057.x
PubMed ID:	16643447
Web of Science ID:	000236738000007
URI:	https://boris.unibe.ch/id/eprint/18993 (FactScience: 1354)