Balloff, Carolin; Albrecht, Philipp; Stucke, Arved-Sebastian; Scala, Lina; Novello, Sveva; Hartmann, Christian Johannes; Meuth, Sven Günther; Schnitzler, Alfons; Penner, Iris-Katharina; Groiss, Stefan Jun (2023). The importance of pyramidal tract integrity for cortical plasticity and related functionality in patients with multiple sclerosis. Frontiers in neurology, 14(1266225), p. 1266225. Frontiers Media S.A. 10.3389/fneur.2023.1266225
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BACKGROUND
Cortical plasticity induced by quadripulse stimulation (QPS) has been shown to correlate with cognitive functions in patients with relapsing-remitting multiple sclerosis (RRMS) and to not be reduced compared to healthy controls (HCs).
OBJECTIVE
This study aimed to compare the degree of QPS-induced plasticity between different subtypes of multiple sclerosis (MS) and HCs and to investigate the association of the degree of plasticity with motor and cognitive functions. We expected lower levels of plasticity in patients with progressive MS (PMS) but not RRMS compared to HCs. Furthermore, we expected to find positive correlations with cognitive and motor performance in patients with MS.
METHODS
QPS-induced plasticity was compared between 34 patients with PMS, 30 patients with RRMS, and 30 HCs using linear mixed-effects models. The degree of QPS-induced cortical plasticity was correlated with various motor and cognitive outcomes.
RESULTS
There were no differences regarding the degree of QPS-induced cortical plasticity between HCs and patients with RRMS (p = 0.86) and PMS (p = 0.18). However, we only found correlations between the level of induced plasticity and both motor and cognitive functions in patients with intact corticospinal tract integrity. Exploratory analysis revealed significantly reduced QPS-induced plasticity in patients with damage compared to intact corticospinal tract integrity (p < 0.001).
CONCLUSION
Our study supports the notion of pyramidal tract integrity being of more relevance for QPS-induced cortical plasticity in MS and related functional significance than the type of disease.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Penner, Iris-Katharina |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1664-2295 |
Publisher: |
Frontiers Media S.A. |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 Dec 2023 12:47 |
Last Modified: |
17 Dec 2023 02:33 |
Publisher DOI: |
10.3389/fneur.2023.1266225 |
PubMed ID: |
38073623 |
Uncontrolled Keywords: |
cortical plasticity motor function pyramidal tract integrity quadripulse stimulation repetitive transcranial magnetic stimulation |
BORIS DOI: |
10.48350/190159 |
URI: |
https://boris.unibe.ch/id/eprint/190159 |
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