Current and Evolving Multimodality Cardiac Imaging in Managing Transthyretin Amyloid Cardiomyopathy.

Alwan, Louhai; Benz, Dominik C; Cuddy, Sarah A M; Dobner, Stephan; Shiri, Isaac; Caobelli, Federico; Bernhard, Benedikt; Stämpfli, Simon F; Eberli, Franz; Reyes, Mauricio; Kwong, Raymond Y; Falk, Rodney H; Dorbala, Sharmila; Gräni, Christoph (2024). Current and Evolving Multimodality Cardiac Imaging in Managing Transthyretin Amyloid Cardiomyopathy. JACC. Cardiovascular imaging, 17(2), pp. 195-211. Elsevier 10.1016/j.jcmg.2023.10.010

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Amyloid transthyretin (ATTR) amyloidosis is a protein-misfolding disease characterized by fibril accumulation in the extracellular space that can result in local tissue disruption and organ dysfunction. Cardiac involvement drives morbidity and mortality, and the heart is the major organ affected by ATTR amyloidosis. Multimodality cardiac imaging (ie, echocardiography, scintigraphy, and cardiac magnetic resonance) allows accurate diagnosis of ATTR cardiomyopathy (ATTR-CM), and this is of particular importance because ATTR-targeting therapies have become available and probably exert their greatest benefit at earlier disease stages. Apart from establishing the diagnosis, multimodality cardiac imaging may help to better understand pathogenesis, predict prognosis, and monitor treatment response. The aim of this review is to give an update on contemporary and evolving cardiac imaging methods and their role in diagnosing and managing ATTR-CM. Further, an outlook is presented on how artificial intelligence in cardiac imaging may improve future clinical decision making and patient management in the setting of ATTR-CM.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Alwan, Louhai, Dobner, Stephan, Shiri Lord, Isaac, Caobelli, Federico, Bernhard, Benedikt, Reyes, Mauricio, Gräni, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1876-7591

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

20 Dec 2023 13:29

Last Modified:

09 Feb 2024 00:15

Publisher DOI:

10.1016/j.jcmg.2023.10.010

PubMed ID:

38099914

Uncontrolled Keywords:

AI CMR DL ML SPECT amyloidosis cardiac ATTR cardiac magnetic resonance echocardiography multimodality imaging scintigraphy

BORIS DOI:

10.48350/190436

URI:

https://boris.unibe.ch/id/eprint/190436

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