Dyab, Reham; Zuccarella-Hackl, Claudia; Princip, Mary; Sivakumar, Sinthujan; Meister-Langraf, Rebecca E; Znoj, Hansjörg; Schmid, Jean-Paul; Barth, Jürgen; Schnyder, Ulrich; von Känel, Roland; Gidron, Yori (2023). Role of Heart Rate Variability in the Association between Myocardial Infarction Severity and Post-Myocardial Infarction Distress. Life, 13(12) MDPI 10.3390/life13122266
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OBJECTIVE
Myocardial infarction (MI) results in mental health consequences, including depression and post-traumatic stress disorder (PTSD). The risk and protective factors of such mental consequences are not fully understood. This study examined the relation between MI severity and future mental health consequences and the moderating role of vagal nerve activity.
METHODS
In a reanalysis of data from the Myocardial Infarction-Stress Prevention Intervention (MI-SPRINT) study, 154 post-MI patients participated. MI severity was measured by the Killip Scale and by troponin levels. Depression and PTSD symptoms were assessed with valid questionnaires, both at 3 and 12 months. Vagal nerve activity was indexed by the heart rate variability (HRV) parameter of the root-mean square of successive R-R differences (RMSSD). Following multivariate analyses, the association between MI severity and distress was examined in patients with low and high HRV (RMSSD = 30 ms).
RESULTS
In the full sample, the Killip index predicted post-MI distress only at 3 months, while troponin predicted distress at 3- and 12-months post-MI. However, HRV moderated the effects of the Killip classification; Killip significantly predicted symptoms of depression and PTSD at 3- and 12-months post-MI, but only in patients with low HRV. Such moderation was absent for troponin.
CONCLUSION
MI severity (Killip classification) predicted post-MI depression and PTSD symptoms, but only in patients with low HRV, suggesting that the vagal nerve is a partial protective (moderating) factor in the relation between Killip score and post-MI distress.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy 07 Faculty of Human Sciences > Institute of Psychology |
UniBE Contributor: |
Znoj, Hans Jörg |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2075-1729 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
27 Dec 2023 15:05 |
Last Modified: |
28 Dec 2023 06:27 |
Publisher DOI: |
10.3390/life13122266 |
PubMed ID: |
38137867 |
Uncontrolled Keywords: |
depressive signs and symptoms heart rate determination moderation myocardial infarction post-traumatic symptoms stress disorders |
BORIS DOI: |
10.48350/190748 |
URI: |
https://boris.unibe.ch/id/eprint/190748 |
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