Giannopoulos, Andreas A; Bolt, Basil; Benz, Dominik C; Messerli, Michael; Von Felten, Elia; Patriki, Dimitri; Gebhard, Catherine; Pazhenkottil, Aju P; Gräni, Christoph; Kaufmann, Philipp A; Buechel, Ronny R; Gaemperli, Oliver (2024). Non-Invasive Assessment of Endothelial Shear Stress in Myocardial Bridges Using Coronary Computed Tomography Angiography. Angiology, 75(4), pp. 367-374. Sage 10.1177/00033197231156637
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Non-Invasive_Assessment_of_Endothelial_Shear_Stress_in_Myocardial_Bridges_Using_Coronary_Computed_Tomography_Angiography.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (934kB) | Preview |
Myocardial bridging (MB) is a segment of coronary arteries with an intramural course, typically spared from atherosclerosis, while the adjacent proximal segment is reported to be atherosclerosis-prone, a phenomenon contributed to local endothelial shear stress (ESS). We aimed to describe the ESS milieu in coronaries with MBs combining coronary computed tomography angiography with computational fluid dynamics and to investigate the association of atherosclerosis presence proximal to MBs with hemorheological characteristics. Patients (n = 36) were identified and 36 arteries with MBs (11 deep and 25 superficial) were analyzed. ESS did not fluctuate 5 mm proximally to MBs vs 5 mm within MBs (0.94 vs 1.06 Pa, p = .56). There was no difference when comparing ESS in the proximal versus mid versus distal MB segments (1.48 vs 1.37 vs 1.9 Pa, p = ns). In arteries with plaques (n = 12), no significant ESS variances were observed around the MB entrance, when analyzing all arteries (p = .81) and irrespective of morphological features of the bridged segment (deep MBs; p = .65, superficial MBs; p = .84). MBs are characterized by homogeneous, atheroprotective ESS, possibly explaining the absence of atherosclerosis within bridged segments. The interplay between ESS and atherosclerosis is potentially not different in arteries with MB compared with arteries without bridges.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Gräni, Christoph |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0003-3197 |
Publisher: |
Sage |
Language: |
English |
Submitter: |
Vjollca Coli |
Date Deposited: |
28 Dec 2023 13:15 |
Last Modified: |
16 Feb 2024 00:15 |
Publisher DOI: |
10.1177/00033197231156637 |
PubMed ID: |
36786297 |
Uncontrolled Keywords: |
computational fluid dynamics coronary atherosclerosis coronary computed tomography angiography endothelial shear stress myocardial bridging |
BORIS DOI: |
10.48350/190885 |
URI: |
https://boris.unibe.ch/id/eprint/190885 |
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