D Magalhães, Andreia; Amstutz, Deborah; Petermann, Katrin; Debove, Ines; Sousa, Mário; Maradan-Gachet, Marie E; Lachenmayer, Martin Lenard; Waskönig, Julia; Murcia-Carretero, Sandra; Diamantaras, Andreas Antonios; Tinkhauser, Gerd; Nowacki, Andreas; Pollo, Claudio; Rodriguez-Blazquez, Carmen; Martinez-Martin, Pablo; Krack, Paul (2024). Subthalamic stimulation has acute psychotropic effects and improves neuropsychiatric fluctuations in Parkinson's disease. BMJ neurology open, 6(1), e000524. British Medical Association 10.1136/bmjno-2023-000524
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BACKGROUND
Subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for motor complications in Parkinson's disease (PD). However, its effects on neuropsychiatric symptoms remain disputed. The aim of this study was to evaluate the effects of STN-DBS on neuropsychiatric symptoms in PD.
METHODS
We retrospectively assessed 26 patients with PD who underwent a preoperative levodopa challenge and postoperative levodopa and stimulation challenges 1 year after STN-DBS. Based on the Neuropsychiatric Fluctuations Scale, Neuropsychiatric State Scores and Neuropsychiatric Fluctuation Indices (NFIs) were calculated. Mixed-effects models with random effects for intercept were used to examine the association of Neuropsychiatric State Score and NFI with the different assessment conditions.
RESULTS
In acute challenge conditions, there was an estimated increase of 15.9 points in the Neuropsychiatric State Score in stimulation ON conditions (95% CI 11.4 to 20.6, p<0.001) and 7.6 points in medication ON conditions (95% CI 3.3 to 11.9, p<0.001). Neuropsychiatric fluctuations induced by levodopa, quantified with NFI, decreased by 35.54% (95% CI 49.3 to 21.8, p<0.001) 1 year after STN-DBS.
CONCLUSIONS
Bilateral STN-DBS at therapeutic parameters has acute psychotropic effects similar to levodopa and can modulate and decrease levodopa-induced neuropsychiatric fluctuations.
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