Epicardial adipose tissue dispersion at CT and recurrent atrial fibrillation after pulmonary vein isolation.

Huber, Adrian Thomas; Fankhauser, Severin; Wittmer, Severin; Chollet, Laureve; Lam, Anna; Maurhofer, Jens; Madaffari, Antonio; Seiler, Jens; Servatius, Helge; Haeberlin, Andreas; Noti, Fabian; Brugger, Nicolas; von Tengg-Kobligk, Hendrik; Gräni, Christoph; Roten, Laurent; Tanner, Hildegard; Reichlin, Tobias (2024). Epicardial adipose tissue dispersion at CT and recurrent atrial fibrillation after pulmonary vein isolation. European radiology, 34(8), pp. 4928-4938. Springer-Verlag 10.1007/s00330-023-10498-2

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OBJECTIVES

Epicardial adipose tissue (EAT) remodeling is associated with atrial fibrillation (AF). Left atrial (LA) EAT dispersion on cardiac CT is a non-invasive imaging biomarker reflecting EAT heterogeneity. We aimed to investigate the association of LA EAT dispersion with AF recurrence after pulmonary vein isolation (PVI).

METHODS

In a prospective registry of consecutive patients undergoing first PVI, mean EAT attenuation values were measured on contrast-enhanced cardiac CT scans in Hounsfield units (HU) within low (- 195 to - 45 HU) and high (- 44 to - 15 HU) threshold EAT compartments around the left atrium (LA). EAT dispersion was defined as the difference between the mean HU values within the two EAT compartments. Continuous variables were compared between groups using the Mann-Whitney U test and cox proportional hazard models were used to calculate hazard ratios of predictors of 1-year AF recurrence.

RESULTS

A total of 208 patients were included, 135 with paroxysmal AF and 73 with persistent AF. LA EAT dispersion was significantly larger in patients with persistent compared to paroxysmal AF (52.6 HU vs. 49.9 HU; p = 0.001). After 1 year of follow-up, LA EAT dispersion above the mean (> 50.8 HU) was associated with a higher risk of AF recurrence (HR 2.3, 95% CI 1.5-3.6; p < 0.001). It retained its predictive value when corrected for age, sex, body mass index, LA volume, and AF type (HR 2.8, 95% CI 1.6-4.6; p < 0.001).

CONCLUSION

A larger LA EAT dispersion on contrast-enhanced cardiac CT scans, reflecting EAT heterogeneity, is independently associated with AF recurrence after PVI.

CLINICAL RELEVANCE STATEMENT

Based on LA EAT dispersion assessment, a more accurate risk stratification and patient selection may be possible based on a pre-procedural cardiac CT when planning PVI.

KEY POINTS

• Epicardial adipose tissue (EAT) remodeling is associated with atrial fibrillation (AF). • A larger left atrial EAT dispersion in a pre-procedural cardiac CT was associated with a higher 1-year AF recurrence risk after pulmonary vein isolation. • A pre-procedural cardiac CT with left atrial EAT dispersion assessment may provide a more accurate risk stratification and patient selection for PVI.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Huber, Adrian Thomas, Fankhauser, Severin, Wittmer, Severin, Lam, Anna, Maurhofer, Jens Rudolf, Madaffari, Antonio, Seiler, Jens, Servatius, Helge Simon (B), Häberlin, Andreas David Heinrich, Noti, Fabian, Brugger, Nicolas Jacques, von Tengg-Kobligk, Hendrik, Gräni, Christoph, Roten, Laurent, Tanner, Hildegard, Reichlin, Tobias Roman

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0938-7994

Publisher:

Springer-Verlag

Language:

English

Submitter:

Pubmed Import

Date Deposited:

11 Jan 2024 09:18

Last Modified:

18 Jul 2024 00:12

Publisher DOI:

10.1007/s00330-023-10498-2

PubMed ID:

38197916

Uncontrolled Keywords:

Adipose tissue Atrial fibrillation Catheter ablation Coronary vessels Multidetector computed tomography

BORIS DOI:

10.48350/191464

URI:

https://boris.unibe.ch/id/eprint/191464

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