Heymer, Emma J; Hawkins, Michael M; Winter, David L; Teepen, Jop C; Sunguc, Ceren; Ronckers, Cécile M; Allodji, Rodrigue S; Alessi, Daniela; Sugden, Elaine; Belle, Fabiën N; Bagnasco, Francesca; Byrne, Julianne; Bárdi, Edit; Garwicz, Stanislaw; Grabow, Desiree; Jankovic, Momcilo; Kaatsch, Peter; Kaiser, Melanie; Michel, Gisela; Schindera, Christina; ... (2024). Risk of subsequent gliomas and meningiomas among 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study. British journal of cancer, 130(6), pp. 976-986. Nature Publishing Group 10.1038/s41416-024-02577-y
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BACKGROUND
Childhood cancer survivors are at risk of subsequent gliomas and meningiomas, but the risks beyond age 40 years are uncertain. We quantified these risks in the largest ever cohort.
METHODS
Using data from 69,460 5-year childhood cancer survivors (diagnosed 1940-2008), across Europe, standardized incidence ratios (SIRs) and cumulative incidence were calculated.
RESULTS
In total, 279 glioma and 761 meningioma were identified. CNS tumour (SIR: 16.2, 95% CI: 13.7, 19.2) and leukaemia (SIR: 11.2, 95% CI: 8.8, 14.2) survivors were at greatest risk of glioma. The SIR for CNS tumour survivors was still 4.3-fold after age 50 (95% CI: 1.9, 9.6), and for leukaemia survivors still 10.2-fold after age 40 (95% CI: 4.9, 21.4). Following cranial radiotherapy (CRT), the cumulative incidence of a glioma in CNS tumour survivors was 2.7%, 3.7% and 5.0% by ages 40, 50 and 60, respectively, whilst for leukaemia this was 1.2% and 1.7% by ages 40 and 50. The cumulative incidence of a meningioma after CRT in CNS tumour survivors doubled from 5.9% to 12.5% between ages 40 and 60, and in leukaemia survivors increased from 5.8% to 10.2% between ages 40 and 50.
DISCUSSION
Clinicians following up survivors should be aware that the substantial risks of meningioma and glioma following CRT are sustained beyond age 40 and be vigilant for symptoms.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Haematology/Oncology 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Belle, Fabien Naomi, Schindera, Christina, Kühni, Claudia |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0007-0920 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
22 Jan 2024 11:07 |
Last Modified: |
29 Mar 2024 23:24 |
Publisher DOI: |
10.1038/s41416-024-02577-y |
PubMed ID: |
38243010 |
BORIS DOI: |
10.48350/191942 |
URI: |
https://boris.unibe.ch/id/eprint/191942 |
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