Lodin, Karin; Espinosa-Ortega, Fabricio; Dastmalchi, Maryam; Vencovsky, Jiri; Andersson, Helena; Chinoy, Hector; Lilleker, James B; Shinjo, Samuel Katsuyuki; Maurer, Britta; Griger, Zoltan; Ceribelli, Angela; Torres-Ruiz, Jiram; Vasquez-Del Mercado, Monica; Leonard, Dag; Alexanderson, Helene; Lundberg, Ingrid E (2024). Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies - A longitudinal study. Seminars in arthritis and rheumatism, 65, p. 152379. Elsevier 10.1016/j.semarthrit.2024.152379
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AIM
To explore if patient global assessment (PGA) is associated with inflammation over time and if associations are explained by other measures of disease activity and function in patients with idiopathic inflammatory myopathies (IIM).
METHODS
PGA and systemic inflammatory markers prospectively collected over five years were retrieved from the International MyoNet registry for 1200 patients with IIM. Associations between PGA, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and creatine kinase (CK) were analyzed using mixed models. Mediation analysis was used to test if the association between PGA and inflammatory markers during the first year of observation could be explained by measures of disease activity and function.
RESULTS
PGA improved, and inflammatory markers decreased during the first year of observation. In the mixed models, high levels of inflammatory markers were associated with worse PGA in both men and women across time points during five years of observation. In men, but not in women, the association between elevated ESR, CRP and poorer PGA was explained by measures of function and disease activity. With a few exceptions, the association between improved PGA and reduced inflammatory markers was partially mediated by improvements in all measures of function and disease activity.
CONCLUSION
Increased levels of systemic inflammation are associated with poorer PGA in patients with IIM. In addition to known benefits of lowered inflammation, these findings emphasize the need to reduce systemic inflammation to improve subjective health in patients with IIM. Furthermore, the results demonstrate the importance of incorporating PGA as an outcome measure in clinical practice and clinical trials.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology |
UniBE Contributor: |
Maurer, Britta |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1532-866X |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
22 Jan 2024 11:05 |
Last Modified: |
22 Mar 2024 00:14 |
Publisher DOI: |
10.1016/j.semarthrit.2024.152379 |
PubMed ID: |
38241913 |
Uncontrolled Keywords: |
Idiopathic inflammatory myopathies Inflammation Myositis Patient reported outcome measures |
BORIS DOI: |
10.48350/191948 |
URI: |
https://boris.unibe.ch/id/eprint/191948 |
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