To, Xuan Vinh; Mohamed, Abdalla Z; Cumming, Paul; Nasrallah, Fatima A (2023). Diffusion tensor imaging and plasma immunological biomarker panel in a rat traumatic brain injury (TBI) model and in human clinical TBI. Frontiers in immunology, 14(1293471) Frontiers Research Foundation 10.3389/fimmu.2023.1293471
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INTRODUCTION
Neuroinflammatory reactions play a significant role in the pathology and long-term consequences of traumatic brain injury (TBI) and may mediate salutogenic processes that white matter integrity. This study aimed to investigate the relationship between inflammatory markers and white matter integrity following TBI in both a rat TBI model and clinical TBI cases.
METHODS
In the rat model, blood samples were collected following a controlled cortical impact (CCI) to assess a panel of inflammatory markers; MR-based diffusion tensor imaging (DTI) was employed to evaluate white matter integrity 60 days post-injury. 15 clinical TBI patients were similarly assessed for a panel of inflammatory markers and DTI post-intensive care unit discharge. Blood samples from healthy controls were used for comparison of the inflammatory markers.
RESULTS
Time-dependent elevations in immunological markers were observed in TBI rats, with a correlation to preserved fractional anisotropy (FA) in white matter. Specifically, TBI-induced increased plasma levels of IL-1β, IL-6, G-CSF, CCL3, CCL5, and TNF-α were associated with higher white matter integrity, as measured by FA. Clinical cases had similar findings: elevated inflammatory markers (relative to controls) were associated with preservation of FA in vulnerable white matter regions.
DISCUSSION
Inflammatory markers in post-TBI plasma samples are ambivalent with respect to prediction of favourable outcome versus a progression to more pervasive pathology and morbidity.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Cumming, Paul |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1664-3224 |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
24 Jan 2024 13:45 |
Last Modified: |
26 Jan 2024 05:56 |
Publisher DOI: |
10.3389/fimmu.2023.1293471 |
PubMed ID: |
38259455 |
Uncontrolled Keywords: |
controlled cortical impact model diffusion tensor imaging fractional anisotropy inflammatory markers traumatic brain injury |
BORIS DOI: |
10.48350/192047 |
URI: |
https://boris.unibe.ch/id/eprint/192047 |
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