Marengo, Giorgio; Bruno, Francesco; Scudeler, Luca; Savoca, Federica; Zugna, Daniela; Isaevska, Elena; Pilgrim, Thomas; Jensen, Lisette Okkels; De Filippo, Ovidio; Richiardi, Lorenzo; De Ferrari, Gaetano Maria; D'Ascenzo, Fabrizio (2024). Comparison among ultra-thin coronary stents: a network meta-analysis. The American journal of cardiology, 216, pp. 9-18. Elsevier 10.1016/j.amjcard.2024.01.018
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BACKGROUND
Ultrathin-strut DES have been related to potential improvement in stent-related outcomes compared to thicker-struts drug-eluting stents (DESs). However, comparisons among different ultrathin devices are lacking.
METHODS
All randomized controlled trials comparing ultrathin (struts thickness < 70 µm) and thicker-struts DESs in an all-comers population were included. Target lesion failure (TLF), as defined by included trials, at 1-year follow-up was the primary endpoint. Overall mortality, myocardial infarction, target lesion revascularization (TLR), and stent thrombosis were the secondary endpoints. Arms of included trials were compared by means of network meta-analysis.
RESULTS
Nine studies encompassing 20081 patients were included, of which 9509 patients had an ultrathin DES: Orsiro (evaluated in 7 arms with 8086 patients), MiStent (one arm with 703 patients), or Supraflex (one arm with 720 patients). At 1-year follow-up, no significant differences were noted for TLF among these ultrathin DES. In particular, Orsiro was associated with a similar risk of TLF compared with Supraflex (RR, 1.07; 95% confidence interval, 0.59-1.78) and showed the highest probability of performing best in terms of TLF, myocardial infarction and TLR.
CONCLUSIONS
Ultrathin DESs are all associated with a comparable risk of TLF as compared with thicker-strut DESs. In terms of TLR and TLF risk, Orsiro was the one with the highest probability of best performances, either compared to other ultrathin DESs or to devices with thicker struts.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Pilgrim, Thomas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1879-1913 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
05 Feb 2024 15:57 |
Last Modified: |
23 Mar 2024 00:14 |
Publisher DOI: |
10.1016/j.amjcard.2024.01.018 |
PubMed ID: |
38301755 |
Uncontrolled Keywords: |
Network meta-analysis Percutaneous coronary intervention Ultrathin drug-eluting stents |
BORIS DOI: |
10.48350/192355 |
URI: |
https://boris.unibe.ch/id/eprint/192355 |
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