Schmeltz, Margaux; Ivanovic, Aleksandra; Schlepütz, Christian M; Wimmer, Wilhelm; Remenschneider, Aaron K; Caversaccio, Marco; Stampanoni, Marco; Anschuetz, Lukas; Bonnin, Anne (2024). The human middle ear in motion: 3D visualization and quantification using dynamic synchrotron-based X-ray imaging. Communications biology, 7(157) Springer Nature 10.1038/s42003-023-05738-6
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The characterization of the vibrations of the middle ear ossicles during sound transmission is a focal point in clinical research. However, the small size of the structures, their micrometer-scale movement, and the deep-seated position of the middle ear within the temporal bone make these types of measurements extremely challenging. In this work, dynamic synchrotron-based X-ray phase-contrast microtomography is used on acoustically stimulated intact human ears, allowing for the three-dimensional visualization of entire human eardrums and ossicular chains in motion. A post-gating algorithm is used to temporally resolve the fast micromotions at 128 Hz, coupled with a high-throughput pipeline to process the large tomographic datasets. Seven ex-vivo fresh-frozen human temporal bones in healthy conditions are studied, and the rigid body motions of the ossicles are quantitatively delineated. Clinically relevant regions of the ossicular chain are tracked in 3D, and the amplitudes of their displacement are computed for two acoustic stimuli.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) 10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research 10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Hearing Research Laboratory |
UniBE Contributor: |
Wimmer, Wilhelm, Caversaccio, Marco, Anschütz, Lukas Peter |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
2399-3642 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
08 Feb 2024 14:41 |
Last Modified: |
09 Feb 2024 05:59 |
Publisher DOI: |
10.1038/s42003-023-05738-6 |
PubMed ID: |
38326549 |
BORIS DOI: |
10.48350/192679 |
URI: |
https://boris.unibe.ch/id/eprint/192679 |
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