Quinoa as phytopharmaceutical? Urinary elimination of ecdysterone after consumption of quinoa alone and in combination with spinach.

Isenmann, Eduard; Yuliandra, Tasha; Touvleliou, Konstantina; Broekmann, Matthias; de la Torre, Xavier; Botrè, Francesco; Diel, Patrick; Parr, Maria Kristina (2024). Quinoa as phytopharmaceutical? Urinary elimination of ecdysterone after consumption of quinoa alone and in combination with spinach. Archiv der Pharmazie, 357(6), e2300689. Wiley 10.1002/ardp.202300689

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The phytosteroid ecdysterone is classified as an anabolic agent and has been included on the monitoring list of the World Anti-Doping Agency since 2020. Therefore, the consumption of food rich in ecdysterone, such as quinoa and spinach, is the focus of a lively debate. Thus, the urinary excretion of ecdysterone and its metabolites in humans was investigated following quinoa consumption alone and in combination with spinach. Eight participants (four male and four female) were included, and they ingested 368 ± 61 g cooked quinoa alone and in combination with 809 ± 115 g spinach after a washout. Post-administration urines were analyzed by LC-MS/MS. After intake of both preparations, ecdysterone and two metabolites were excreted in the urine. The maximum concentration of ecdysterone ranged from 0.44 to 5.5 µg/mL after quinoa and from 0.34 to 4.1 µg/mL after quinoa with spinach. The total urinary excreted amount as parent drug plus metabolites was 2.61 ± 1.1% following quinoa intake and 1.7 ± 0.9% in combination with spinach. Significant differences were found in the total urinary excreted amount of ecdysterone, 14-deoxy-ecdysterone, and 14-deoxy-poststerone. Only small portions of ecdysterone from quinoa and the combination with spinach were excreted in the urine, suggesting that both quinoa and spinach are poor sources of ecdysterone in terms of bioavailability.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery

UniBE Contributor:

Broekmann, Matthias Alexander

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1521-4184

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

28 Feb 2024 14:08

Last Modified:

04 Jun 2024 00:13

Publisher DOI:

10.1002/ardp.202300689

PubMed ID:

38400693

Uncontrolled Keywords:

14-deoxy-ecdysterone 14-deoxy-poststerone quinoa spinach urinary excretion

BORIS DOI:

10.48350/193225

URI:

https://boris.unibe.ch/id/eprint/193225

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