Gäckler, Anja; Ertasoglu, Onurcan; Rohn, Hana; Friebus-Kardash, Justa; Ickerott, Philipp-Christopher; Witzke, Oliver; Kribben, Andreas; Vogt, Bruno; Dahdal, Suzan; Arampatzis, Spyridon; Eisenberger, Ute (2024). Urinary Biomarkers for Cell Cycle Arrest TIMP-2 and IGFBP7 for Prediction of Graft Function Recovery after Kidney Transplantation. International journal of molecular sciences, 25(8) MDPI 10.3390/ijms25084169
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TIMP-2 and IGFBP7 have been identified and validated for the early detection of renal injury in critically ill patients, but data on recovery of allograft function after kidney transplantation (KTx) are scarce. In a prospective observational multicenter cohort study of renal transplant recipients, urinary [TIMP-2] × [IGFBP7] was evaluated daily from day 1 to 7 after KTx. Different stages of early graft function were defined: immediate graft function (IGF) (decrease ≥ 10% in serum creatinine (s-crea) within 24 h post KTx); slow graft function (SGF) (decrease in s-crea < 10% within 24 h post KTx); and delayed graft function (DGF) (any dialysis needed within the first week after KTx). A total of 186 patients were analyzed. [TIMP-2] × [IGFBP7] was significantly elevated as early as day 1 in patients with DGF compared to SGF and IGF. ROC analysis of [TIMP-2] × [IGFBP7] at day 1 post-transplant for event "Non-DGF" revealed a cut-off value of 0.9 (ng/mL)2/1000 with a sensitivity of 87% and a specificity of 71%. The positive predictive value for non-DGF was 93%. [TIMP-2] × [IGFBP7] measured at day 1 after KTx can predict early recovery of transplant function and is therefore a valuable biomarker for clinical decision making.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Vogt, Bruno, Dahdal, Suzan, Arampatzis, Spyridon |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1422-0067 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
01 May 2024 12:06 |
Last Modified: |
02 May 2024 15:40 |
Publisher DOI: |
10.3390/ijms25084169 |
PubMed ID: |
38673754 |
Uncontrolled Keywords: |
IGFBP7 TIMP-2 graft function recovery kidney transplantation |
BORIS DOI: |
10.48350/196308 |
URI: |
https://boris.unibe.ch/id/eprint/196308 |
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