Friedli, Christoph; Krajnc, Nik; Hammer, Helly N; Marti, Stefanie; Zrzavy, Tobias; Evangelopoulos, Maria E; Kapsali, Ioanna; Rommer, Paulus; Berger, Thomas; Chan, Andrew; Bsteh, Gabriel; Hoepner, Robert (2024). Different lymphocyte counts of multiple sclerosis patients treated with ofatumumab and ocrelizumab: A retrospective observational study. Journal of central nervous system disease, 16(11795735241249644) Sage 10.1177/11795735241249644
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INTRODUCTION
Patients with Multiple Sclerosis (pwMS) treated with anti-CD20 (cluster of differentiation) monoclonal antibodies (mAbs) such as ocrelizumab (OCR) and ofatumumab (OFA) show a reduction mainly of B-lymphocytes, but also other lymphocyte subsets can be affected by these treatments. There is limited data on differences between lymphocyte subset counts of pwMS after treatment initiation with OCR or OFA.
OBJECTIVE
To compare lymphocyte subset counts after treatment initiation in pwMS treated with OCR and OFA.
METHODS
We analyzed 22 pwMS initiated on OFA and 56 sex-, age- and MS course matched pwMS initiated on OCR from 2 prospectively collected observational MS databases (Bern [n: OFA 14, OCR 44] and Vienna [n: OFA 8, OCR 12]) statistically comparing lymphocyte subset counts (Mann Whitney Test).
RESULTS
We found that pwMS treated with OCR showed a stronger reduction of CD20 B-lymphocytes (P = .001), and a trend towards lower counts of CD8+ T cells (P = .056) compared to pwMS treated with OFA, whereas reduction of total lymphocyte, CD4+ lymphocyte and NK cell count was equally distributed between both treatments.
CONCLUSION
Different effects on lymphocyte subpopulations appear to be present in pwMS after treatment initiation with different anti-CD20 mAbs. Further studies are needed to determine potential effects on anti-CD20 treatment efficacy as well as treatment associated risks such as failed vaccinations and infections.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Friedli, Christoph Daniel, Hammer, Helly Noemi, Marti, Stefanie, Chan, Andrew Hao-Kuang, Hoepner, Robert |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1179-5735 |
Publisher: |
Sage |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
08 May 2024 11:57 |
Last Modified: |
09 May 2024 01:39 |
Publisher DOI: |
10.1177/11795735241249644 |
PubMed ID: |
38711956 |
Uncontrolled Keywords: |
Immunotherapy MS aCD20 anti-CD20 kesimpta ocrevus white blood cells |
BORIS DOI: |
10.48350/196594 |
URI: |
https://boris.unibe.ch/id/eprint/196594 |
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