Li, Ruijie; Barker, Alan R; Vlachopoulos, Dimitris; Paris, Dewi; Schindera, Christina; Belle, Fabiën N; Revuelta Iniesta, Raquel (2024). The Role of Diet in the Cardiovascular Health of Childhood Cancer Survivors-A Systematic Review. Nutrients, 16(9), p. 1315. MDPI 10.3390/nu16091315
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BACKGROUND
Childhood cancer survivors (CCSs) face an increased risk of cardiovascular disease (CVD). This systematic review aims to provide the first synthesis of observational and interventional studies on the relationship between diet and cardiovascular health in CCSs.
METHODS
A comprehensive search was conducted for studies published between 1990 and July 2023 in PubMed, MEDLINE, CINAHL, Child Development & Adolescent Studies, and Cochrane Library. Eligible studies included observational and interventional studies examining the associations or effects of dietary factors on CVD incidence, cardiac dysfunction, or CVD risk factors in CCSs diagnosed before age 25 years.
RESULTS
Ten studies met the inclusion criteria (nine observational and one interventional). Collectively, they comprised 3485 CCSs (male, 1734; female, 1751). The outcomes examined across observational studies included characteristics of obesity, diabetes biomarkers, hypertension indicators, dyslipidaemia biomarkers, and metabolic syndrome. The evidence suggested that greater adherence to healthy diets was associated with lower body mass index, blood pressure, glucose, and triglycerides and higher high-density lipoprotein cholesterol. The 12-week lifestyle intervention study in childhood leukaemia survivors found no impact on obesity indicators.
CONCLUSION
The review results indicate the potentially protective effects of healthy diets. However, the available research remains preliminary and limited, underscoring the need for more rigorous, adequately powered studies.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Schindera, Christina, Belle, Fabien Naomi |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
2072-6643 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 May 2024 08:40 |
Last Modified: |
07 Aug 2024 15:44 |
Publisher DOI: |
10.3390/nu16091315 |
PubMed ID: |
38732563 |
Uncontrolled Keywords: |
cardiac dysfunction cardiovascular disease risk factors cardiovascular diseases childhood cancer survivors diet diet recommendations |
BORIS DOI: |
10.48350/196707 |
URI: |
https://boris.unibe.ch/id/eprint/196707 |
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